ArticleMediterranean journal of hematology and infectious diseases2012
Sickle cell anaemia and malaria.
Article in Mediterranean journal of hematology and infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 1 of them a synthesis that pooled it.
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Who cites it
86 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
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- Genetic variants in red blood cell adhesion-related genes influence the severity of sickle cell anemia in a malaria-endemic region : Short title: Genetic variants in red blood cell adhesion-related genes in sickle cell anemia.Molecular biology reports · 2026Article
- Unlocking Ethiopia's genomic landscape and its global significance: a call for inclusive genomics research.Human genomics · 2026Review
- Incidence of clinical malaria and asymptomatic parasitaemia among African children living with sickle cell disease: a multicentre prospective longitudinal cohort study protocol.BMJ public health · 2026Article
- Balancing immunity: disease risk mutation can be beneficial.Trends in immunology · 2025Article
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- Performance of a smartphone-based malaria screener in detecting malaria in people living with Sickle cell disease.PLOS digital health · 2025Article
- Risk factors associated with pain episodes among sickle cell patients that visited Mulago National Referral Hospital-Uganda.BMC health services research · 2025Article
- Haematological abnormalities as diagnostic indicators of malaria in returning travellers: a retrospective study at Mohamed V Military Instruction Hospital.Access microbiology · 2025Article
- "I want to help my body": Acceptability of malaria chemoprevention among children with sickle cell anaemia and their caregivers in Malawi and Uganda.PLOS global public health · 2025Article
- Sickle Cell Disease.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Review
- Role of Divalent Cations in Infections in Host-Pathogen Interaction.International journal of molecular sciences · 2024Review
- Beliefs negatively mediate adolescents' and adults' knowledge about sickle cell disease prevention and relationship choices; a one-center exploratory study in Central Region, Ghana.Archives of public health = Archives belges de sante publique · 2024Article
- Building genomic capacity for precision health in Africa.Nature medicine · 2024Review
- Blood count changes in malaria patients according to blood groups (ABO/Rh) and sickle cell trait.Malaria journal · 2024Observational
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- Hypertension Increases Susceptibility to Experimental Malaria in Mice.Function (Oxford, England) · 2024Article
- Therapeutics for sickle cell disease intravascular hemolysis.Frontiers in physiology · 2024Review
- Clinical and laboratory factors associated with splenic dysfunction among patients with sickle cell disease in a malaria endemic region.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sickle cell anaemia is a major chapter within haemolytic anaemias; at the same time, its epidemiology is a remarkable signature of the past and present world distribution of Plasmodium falciparum malaria. In this brief review, in keeping with the theme of this journal, we focus on the close and complex relationship betweeen this blood disease and this infectious disease. On one hand, heterozygotes for the sickle gene (AS) are relatively protected against the danger of dying of malaria, as now firmly established through a number of clinical field studies from different parts of Africa. In addition, experimental work is consistent with a plausibile mechanism: namely, that in AS heterozygotes P falciparum-infected red cells sickle preferentially and are then removed by macrophages. On the other hand, patients who are homozygous for the sickle gene and therefore suffer from sickle cell anaemia (SCA) are highly susceptible to the lethal effects of malaria. The simplest explanation of this fact is that malaria makes the anaemia of SCA more severe; in addition, in SCA there is often hyposplenism, which reduces clearance of parasites. From the point of view of public health it is important that in malaria-endemic countries patients with SCA, and particularly children, be protected from malaria by appropriate prophylaxis.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.