Evidence map›Paper›PMID 23170179›Full record

ReviewViruses2012

Emerging themes from EBV and KSHV microRNA targets.

Dhivya Ramalingam, Philippe Kieffer-Kwon, Joseph M Ziegelbauer

Open access · goldAbstract readReview
In one paragraph

Review in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 62 citations in OpenAlex.

  1. Review
  2. Review
  3. Non-coding RNA Networks in Infection.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  4. Review
  5. Review
  6. Article
  7. Cell death pathways and viruses: Role of microRNAs.Molecular therapy. Nucleic acids · 2021
    Review
  8. Metabolic Control by DNA Tumor Virus-Encoded Proteins.Pathogens (Basel, Switzerland) · 2021
    Review
  9. Article
  10. Microbiome in human cancers.Access microbiology · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Epstein-Barr virus-encoded microRNAs as regulators in host immune responses.International journal of biological sciences · 2018
    Review
  19. Review
  20. KSHV microRNAs: Tricks of the Devil.Trends in microbiology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dhivya RamalingamHIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. dhivya.ramalingam@nih.gov
Philippe Kieffer-Kwon
Joseph M Ziegelbauer
National Institutes of Health · USNational Cancer Institute · US

Funding

Functions of KSHV microRNAs and circular RNAsZIABC011176 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI ZIEGELBAUER, JOSEPH · 2009 to 2025
$14.0M
Intramural NIH HHS
6 · The paper itself

Abstract

EBV and KSHV are both gamma-herpesviruses which express multiple viral microRNAs. Various methods have been used to investigate the functions of these microRNAs, largely through identification of microRNA target genes. Surprisingly, these related viruses do not share significant sequence homology in their microRNAs. A number of reports have described functions of EBV and KSHV microRNA targets, however only three experimentally validated target genes have been shown to be targeted by microRNAs from both viruses. More sensitive methods to identify microRNA targets have predicted approximately 60% of host targets could be shared by EBV and KSHV microRNAs, but by targeting different sequences in the host targets. In this review, we explore the similarities of microRNA functions and targets of these related viruses.

Indexed as

Gene Expression RegulationHerpesvirus 4, HumanHerpesvirus 8, HumanHumansMicroRNAsRNA, ViralVirulence FactorsMicroRNAsRNA, ViralVirulence FactorsEBVHHV4HHV8KSHVmicroRNAsmiRNAs

Identifiers

PMID23170179
PMCPMC3499826
OpenAlexW2029488119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.