ArticleViruses2012
Renal alterations in feline immunodeficiency virus (FIV)-infected cats: a natural model of lentivirus-induced renal disease changes.
Article in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Causes of morbidity and mortality in free-ranging Eurasian lynx (Lynx lynx) in Switzerland, 2000-2022.PloS one · 2026Article
- High prevalence of renal amyloidosis in cats in an overcrowded colony.The Journal of veterinary medical science · 2025Article
- Feline immunodeficiency virus: current insights into pathogenesis, clinical impact, and advances in treatment and vaccine development.Frontiers in veterinary science · 2025Review
- The Late Asymptomatic and Terminal Immunodeficiency Phases in Experimentally FIV-Infected Cats-A Long-Term Study.Viruses · 2023Article
- AA-amyloidosis in cats (Felis catus) housed in shelters.PloS one · 2023Article
- Article
- Chaphamaparvovirus antigen and nucleic acids are not detected in kidney tissues from cats with chronic renal disease or immunocompromised cats.Veterinary pathology · 2022Article
- Prevalence of autoantibodies that bind to kidney tissues in cats and association risk with antibodies to feline viral rhinotracheitis, calicivirus, and panleukopenia.Journal of veterinary science · 2021Article
- Review
- Management of Suspected Cases of Feline Immunodeficiency Virus Infection in Eurasian Lynx (Frontiers in veterinary science · 2021Article
- Immune-complex glomerulonephritis in cats: a retrospective study based on clinico-pathological data, histopathology and ultrastructural features.BMC veterinary research · 2019Article
- Article
- Applications of the FIV Model to Study HIV Pathogenesis.Viruses · 2018Review
- Systolic blood pressure, routine kidney variables and renal ultrasonographic findings in cats naturally infected with feline immunodeficiency virus.Journal of feline medicine and surgery · 2017Article
- Risk and protective factors for cats with naturally occurring chronic kidney disease.Journal of feline medicine and surgery · 2017Article
- Epidemiological and pathological study of feline morbillivirus infection in domestic cats in Japan.BMC veterinary research · 2016Article
- Serum and urinary cystatin C in cats with feline immunodeficiency virus infection and cats with hyperthyroidism.Journal of feline medicine and surgery · 2016Article
- Feline CKD: Pathophysiology and risk factors--what do we know?Journal of feline medicine and surgery · 2013Review
- Feline immunodeficiency virus latency.Retrovirology · 2013Review
- Amyloidosis in association with spontaneous feline immunodeficiency virus infection.Journal of feline medicine and surgery · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus (HIV) is associated with several renal syndromes including acute and chronic renal failures, but the underlying pathogenic mechanisms are unclear. HIV and feline immunodeficiency virus (FIV) share numerous biological and pathological features, including renal alterations. We investigated and compared the morphological changes of renal tissue of 51 experimentally and 21 naturally infected cats. Compared to the latter, the experimentally infected cats exhibited some mesangial widening and glomerulonephritis, milder proteinuria, and lower tubular and interstitial alterations. The numbers of giant protein tubular casts and tubular microcysts were also lower. In contrast, diffuse interstitial infiltrates and glomerular and interstitial amyloidosis were detected only in naturally infected cats. Similar alterations are found in HIV infected patients, thus supporting the idea of a causative role of FIV infection in renal disease, and underlining the relevance of the FIV and its natural host as an animal model for investigating lentivirus-associated nephropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.