ArticleExperimental and therapeutic medicine2012
Protective effects of capillary artemisia polysaccharide on oxidative injury to the liver in rats with obstructive jaundice.
Article in Experimental and therapeutic medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Novel Antiviral Efficacy ofPlants (Basel, Switzerland) · 2022Article
- Effects of Scoparone on differentiation, adhesion, migration, autophagy and mineralization through the osteogenic signalling pathways.Journal of cellular and molecular medicine · 2022Article
- Quality Evaluation ofJournal of analytical methods in chemistry · 2021Article
- Herba Artemisiae Capillaris Extract Prevents the Development of Streptozotocin-Induced Diabetic Nephropathy of Rat.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Nesfatin-1 alleviates extrahepatic cholestatic damage of liver in rats.Bosnian journal of basic medical sciences · 2016Article
- A Survey of Therapeutic Effects of Artemisia capillaris in Liver Diseases.Evidence-based complementary and alternative medicine : eCAM · 2015Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obstructive jaundice is a condition caused by blockage of the flow of bile out of the liver. This results in an overflow of bile and its by-products into the blood, and bile excretion from the body is incomplete. Untreated, obstructive jaundice can lead to serious infection that spreads to other parts of the body. We examined the protective effect of capillary artemisia polysaccharide on oxidative damage to the liver in growing rats with obstructive jaundice (OJ). Growing male Wistar rats (n=40, age 3-4 weeks) were randomly divided into four groups (n=10 in each group): normal control group, sham group, OJ group and OJ with capillary artimesia polysaccha-ride treatment group (study group). The rats of the OJ group and the study group were subjected to common bile dust ligation, while the sham group had the bile duct mobilized but not ligated. The rats of the study group recieved 5 ml/kg capillary artimesia polysaccharide (0.5 g/ml) by intraperitoneal (i.p.) injection once daily while the other groups were administered 5 ml/kg saline by i.p. injection. After 4 weeks, the rats were sacrificed to obtain liver weight and to compute the liver coefficient. Additional measures included liver homogenate malondialdehyde (MDA) and the activity levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT). The liver weight and liver coefficient of rats in the study group were lower than those in the OJ group and higher than those in the control and sham groups (P<0.05). Liver homogenate MDA content in the study group rats was lower than that in the OJ group and higher than that in the control and sham group (P<0.05). SOD, GSH-Px and CAT activities were higher in the study group rats than those in the OJ group and lower than those in other groups (P<0.05). Capillary artimesia capillary artemisia polysaccharide protects the liver from oxidative damage and improves antioxidant defense in growing rats with obstructive jaundice.
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Registered trials
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