ArticleMarine drugs2012
Antioxidant and anti-protease activities of diazepinomicin from the sponge-associated Micromonospora strain RV115.
Article in Marine drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 76 citations in OpenAlex.
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- Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds.BMC microbiology · 2023Article
- New Insights on Biological Activities, Chemical Compositions, and Classifications of Marine Actinomycetes Antifouling Agents.Microorganisms · 2023Review
- The Effects of a High Concentration of Dissolved Oxygen on Actinobacteria from Lake Baikal.Metabolites · 2023Article
- Nematicidal Metabolites from the ActinomyceteMicroorganisms · 2022Article
- Indispensable role of microbes in anticancer drugs and discovery trends.Applied microbiology and biotechnology · 2022Review
- Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria.Natural product reports · 2021Review
- Natural Products from Actinomycetes Associated with Marine Organisms.Marine drugs · 2021Review
- Sponges and Their Symbionts as a Source of Valuable Compounds in Cosmeceutical Field.Marine drugs · 2021Review
- Sponge-associated spSaudi journal of biological sciences · 2021Article
- Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling.Antibiotics (Basel, Switzerland) · 2020Article
- The genusRSC advances · 2020Review
- Actinomycetes from the Red Sea SpongeMicroorganisms · 2020Article
- Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated ActinomycetesMarine drugs · 2020Article
- Potential of rare actinomycetes in the production of metabolites against multiple oxidant agents.Pharmaceutical biology · 2018Article
- Complete Genome of Micromonospora sp. Strain B006 Reveals Biosynthetic Potential of a Lake Michigan Actinomycete.Journal of natural products · 2018Article
- Draft Genome Sequence of Micromonospora sp. Strain WMMA1996, a Marine Sponge-Associated Bacterium.Genome announcements · 2018Article
- First Record of Microbiomes of Sponges Collected From the Persian Gulf, Using Tag Pyrosequencing.Frontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diazepinomicin is a dibenzodiazepine alkaloid with an unusual structure among the known microbial metabolites discovered so far. Diazepinomicin was isolated from the marine sponge-associated strain Micromonospora sp. RV115 and was identified by spectroscopic analysis and by comparison to literature data. In addition to its interesting preclinical broad-spectrum antitumor potential, we report here new antioxidant and anti-protease activities for this compound. Using the ferric reducing antioxidant power (FRAP) assay, a strong antioxidant potential of diazepinomicin was demonstrated. Moreover, diazepinomicin showed a significant antioxidant and protective capacity from genomic damage induced by the reactive oxygen species hydrogen peroxide in human kidney (HK-2) and human promyelocytic (HL-60) cell lines. Additionally, diazepinomicin inhibited the proteases rhodesain and cathepsin L at an IC₅₀ of 70-90 µM. It also showed antiparasitic activity against trypomastigote forms of Trypanosoma brucei with an IC₅₀ of 13.5 µM. These results showed unprecedented antioxidant and anti-protease activities of diazepinomicin, thus further highlighting its potential as a future drug candidate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.