ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
Factors that explain excretion of enteric pathogens by persons without diarrhea.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Association of enteropathogen detection with diarrhoea by age and high versus low child mortality settings: a systematic review and meta-analysis.The Lancet. Global health · 2021Pooled it
- Birth Cohort Studies Assessing Norovirus Infection and Immunity in Young Children: A Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Pooled it
- Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2014Pooled it
- Characterization of the pathophysiological determinants of diarrheagenic Escherichia coli infection using a challenge model in healthy adults.Scientific reports · 2021Trial
- Prevalence and diversity of enteric pathogens among cholera treatment centre patients with acute diarrhea in Uvira, Democratic Republic of Congo.BMC infectious diseases · 2020Trial
- Associations between enteric pathogen carriage and height-for-age, weight-for-age and weight-for-height in children under 5 years old in urban Dhaka, Bangladesh.Epidemiology and infection · 2020Trial
- Comparable Norovirus Shedding in Symptomatic and Asymptomatic Individuals: A Hospital-Based Study in Bangladesh.Open forum infectious diseases · 2026Article
- Prevalence of enteric pathogens in mothers and children from communities in the La Paz River Basin Bolivia; associations with water, sanitation, and hygiene conditions.Journal of water and health · 2026Article
- Leveraging Data From a Longitudinal Birth Cohort to Improve Attribution of Diarrhea Etiology Among Children in Low-Resource Settings.The Journal of infectious diseases · 2025Article
- Clinico-Epidemiological Characteristics of Symptomatic and Asymptomatic Enterotoxigenic and Enteropathogenic Escherichia Coli Diarrhea and Impact on Child Growth.The American journal of tropical medicine and hygiene · 2025Article
- A TaqMan qPCR for precise detection and quantification of diarrheagenic Escherichia coli.Scientific reports · 2025Article
- Use of gastrointestinal syndromic multiplex molecular assays and detection ofJournal of clinical microbiology · 2025Article
- EnteropathogenicClinical case reports · 2025Article
- Why are so many enteric pathogen infections asymptomatic? Pathogen and gut microbiome characteristics associated with diarrhea symptoms and carriage of diarrheagenicGut microbes · 2023Article
- Network analysis of patterns and relevance of enteric pathogen co-infections among infants in a diarrhea-endemic setting.PLoS computational biology · 2023Article
- Symptomatic and Asymptomatic Campylobacter Infections and Child Growth in South Asia: Analyzing Data from the Global Enteric Multicenter Study.The American journal of tropical medicine and hygiene · 2023Article
- Exploring Survey-Based Water, Sanitation, and Animal Associations With Enteric Pathogen Carriage: Comparing Results in a Cohort of Cases With Moderate-to-Severe Diarrhea to Those in Controls in the Vaccine Impact on Diarrhea in Africa (VIDA) Study, 2015-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Prevalence of diarrheagenic Escherichia coli and impact on child health in Cap-Haitien, Haiti.PLOS global public health · 2023Article
- Prevalence and genotypes distribution of group A rotavirus among outpatient children under 5 years with acute diarrhea in Shanghai, China, 2012-2018.BMC gastroenterology · 2022Article
- Prevalence of diarrhoeal pathogens among children under five years of age with and without diarrhoea in Guinea-Bissau.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excretion of enteropathogens by subjects without diarrhea influences our appreciation of the role of these pathogens as etiologic agents. Characteristics of the pathogens and host and environmental factors help explain asymptomatic excretion of diarrheal pathogens by persons without diarrhea. After causing acute diarrhea followed by clinical recovery, some enteropathogens are excreted asymptomatically for many weeks. Thus, in a prevalence survey of persons without diarrhea, some may be excreting pathogens from diarrheal episodes experienced many weeks earlier. Volunteer challenges with Vibrio cholerae O1, enterotoxigenic Escherichia coli (ETEC), enteropathogenic E. coli, Campylobacter jejuni, and Giardia lamblia document heterogeneity among enteropathogen strains, with some inexplicably not eliciting diarrhea. The immune host may not manifest diarrhea following ingestion of a pathogen but may nevertheless asymptomatically excrete. Some human genotypes render them less susceptible to symptomatic or severe diarrheal infection with certain pathogens such as Vibrio cholerae O1 and norovirus. Pathogens in stools of individuals without diarrhea may reflect recent ingestion of inocula too small to cause disease in otherwise susceptible hosts or of animal pathogens (eg, bovine or porcine ETEC) that do not cause human illness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.