ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2012
The Global Enteric Multicenter Study (GEMS): impetus, rationale, and genesis.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Etiology-specific incidence and mortality of diarrheal diseases in the African region: a systematic review and meta-analysis.BMC public health · 2024Pooled it
- Shared sanitation versus individual household latrines: a systematic review of health outcomes.PloS one · 2014Pooled it
- Clinical Trial of an Oral Live Shigella sonnei Vaccine Candidate, WRSS1, in Thai Adults.Clinical and vaccine immunology : CVI · 2016Trial
- Burden of Shigella infection in children under five years living in a peri-urban area of Ouagadougou, Burkina Faso: A community-based cohort study.PLoS neglected tropical diseases · 2026Article
- Machine learning-based prediction of shigellosis in children under five: development and internal validation of a prediction model.BMJ health & care informatics · 2026Article
- Genomic Insights and Antimicrobial Resistance Profiling of DiarrheagenicMicroorganisms · 2026Article
- Infectious Diarrhea in Early Childhood across the Global South: Etiologic Diversity and Pathogenic Mechanisms.ACS infectious diseases · 2026Review
- Thirty-one-year trends in diarrheal mortality and disability-adjusted life years attributable to lack of handwashing facilities.Tropical medicine and health · 2026Article
- Development of an enteric pathogen multiplex immunoassay to measure antibody responses in blood and saliva for integrated serology applications.Journal of immunological methods · 2025Article
- Cost of diarrhoea: a household perspective from seven countries in the Global Enteric Multicentre Study (GEMS).BMJ paediatrics open · 2025Article
- Article
- Infectious diseases burden and antibiotic prescribing patterns among primary care patients in Harare, Zimbabwe - a cross-sectional analysis.PLOS global public health · 2025Article
- High prevalence of enterotoxigenicFrontiers in microbiology · 2025Article
- Diarrhoeagenic Escherichia coli associated with childhood diarrhoea in Osun state, Nigeria.BMC infectious diseases · 2024Article
- Data Management in Multicountry Consortium Studies: The Enterics For Global Health (EFGH)Open forum infectious diseases · 2024Article
- Developing a digital data platform for surveillance of food and water-borne pathogens in North East India: insight for public health advocacy.Frontiers in public health · 2024Article
- Predictive modeling for infectious diarrheal disease in pediatric populations: A systematic review.Learning health systems · 2024Article
- Comparative prevalence of diarrheagenicThe Pan African medical journal · 2024Article
- The Adjuvant Combination of dmLT and Monophosphoryl Lipid A Activates the Canonical, Nonpyroptotic NLRP3 Inflammasome in Dendritic Cells and Significantly Interacts to Expand Antigen-Specific CD4 T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Survey-Based Assessment of Water, Sanitation, and Animal-Associated Risk Factors for Moderate-to-Severe Diarrhea in the Vaccine Impact on Diarrhea in Africa (VIDA) Study: The Gambia, Mali, and Kenya, 2015-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrheal disease remains one of the top 2 causes of young child mortality in the developing world. Whereas improvements in water/sanitation infrastructure and hygiene can diminish transmission of enteric pathogens, vaccines can also hasten the decline of diarrheal disease morbidity and mortality. From 1980 through approximately 2004, various case/control and small cohort studies were undertaken to address the etiology of pediatric diarrhea in developing countries. Many studies had methodological limitations and came to divergent conclusions, making it difficult to prioritize the relative importance of different pathogens. Consequently, in the first years of the millennium there was no consensus on what diarrheal disease vaccines should be developed or implemented; however, there was consensus on the need for a well-designed study to obtain information on the etiology and burden of more severe forms of diarrheal disease to guide global investment and implementation decisions. Accordingly, the Global Enteric Multicenter Study (GEMS) was designed to overcome drawbacks of earlier studies and determine the etiology and population-based burden of pediatric diarrheal disease. GEMS, which includes one of the largest case/control studies of an infectious disease syndrome ever undertaken (target approximately 12,600 analyzable cases and 12,600 controls), was rolled out in 4 sites in sub-Saharan Africa (Gambia, Kenya, Mali, Mozambique) and 3 in South Asia (Bangladesh, India, Pakistan), with each site linked to a population under demographic surveillance (total approximately 467,000 child years of observation among children <5 years of age). GEMS data will guide investment and help prioritize strategies to mitigate the morbidity and mortality of pediatric diarrheal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.