Evidence map›Paper›PMID 23169704›Full record

ReviewJournal of biochemical and molecular toxicology2013

Genes of innate immunity and the biological response to inhaled ozone.

Zhuowei Li, Robert M Tighe, Feifei Feng, Julie G Ledford, John W Hollingsworth

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of biochemical and molecular toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. [The role of ozone in the pathogenesis of allergic rhinitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Zhuowei LiDepartment of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Robert M Tighe
Feifei Feng
Julie G Ledford
John W Hollingsworth
Duke Medical Center · USDuke University Hospital · US

Funding

Surfactant Protein-A Regulation of Innate Immunityin AsthmaP01AI081672 · NIAID · DUKE UNIVERSITY · PI SUNDY, JOHN S · 2009 to 2013
$7.4M
OZONE PRIMES PULMONARY INNATE IMMUNITYR01ES016126 · NIEHS · OHIO STATE UNIVERSITY · PI HOLLINGSWORTH, JOHN W · 2008 to 2012
$2.3M
EXTRACELLULAR MATRIX, INNATE IMMUNITY, AND OZONE-INDUCED AIRWAYS DISEASER01ES020350 · NIEHS · OHIO STATE UNIVERSITY · PI WEWERS, MARK DAMIAN · 2012 to 2016
$2.0M
The role of SP-A in Mp-induced exacerbations during allergic airway disease.R00HL111151 · NHLBI · UNIVERSITY OF ARIZONA · PI LEDFORD, JULIE GUNNELLS · 2014 to 2016
$716k
Regulation of Lung Fibrosis by Alternatively Activated Macrophages and Arginase-1K08HL105537 · NHLBI · DUKE UNIVERSITY · PI TIGHE, ROBERT MATTHEW · 2012 to 2016
$492k
Environmenal epigenitics and innate immunityR21ES020426 · NIEHS · DUKE UNIVERSITY · PI BRASS, DAVID M, HOLLINGSWORTH, JOHN W · 2011 to 2012
$432k
The role of SP-A in Mp-induced exacerbations during allergic airway disease.K99HL111151 · NHLBI · DUKE UNIVERSITY · PI LEDFORD, JULIE GUNNELLS · 2012 to 2013
$201k
NHLBI NIH HHS HL105537NHLBI NIH HHS HL111151NHLBI NIH HHS K08 HL105537NHLBI NIH HHS K99 HL111151NHLBI NIH HHS R00 HL111151NIAID NIH HHS AI081672NIAID NIH HHS P01 AI081672NIEHS NIH HHS ES016126NIEHS NIH HHS ES020350NIEHS NIH HHS ES020426NIEHS NIH HHS R01 ES016126NIEHS NIH HHS R01 ES020350NIEHS NIH HHS R21 ES020426
6 · The paper itself

Abstract

Ambient ozone has a significant impact on human health. We have made considerable progress in understanding the fundamental mechanisms that regulate the biological response to ozone. It is increasingly clear that genes of innate immunity play a central role in both infectious and noninfectious lung disease. The biological response to ambient ozone provides a clinically relevant environmental exposure that allows us to better understand the role of innate immunity in noninfectious airways disease. In this brief review, we focus on (1) specific cell types in the lung modified by ozone, (2) ozone and oxidative stress, (3) the relationship between genes of innate immunity and ozone, (4) the role of extracellular matrix in reactive airways disease, and (5) the effect of ozone on the adaptive immune system. We summarize recent advances in understanding the mechanisms that ozone contributes to environmental airways disease.

Indexed as

Adaptive ImmunityAdministration, InhalationExtracellular MatrixHumansImmunity, InnateLungOxidative StressOzoneToll-Like ReceptorsOzoneToll-Like Receptors

Identifiers

PMID23169704
PMCPMC3733118
OpenAlexW1558062727

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.