ArticleProceedings of the National Academy of Sciences of the United States of America2012
Mechanism for adaptive remodeling of the bacterial flagellar switch.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Cellular scale search and funneling drive bacterial penetration of extreme confinements.Communications physics · 2026Article
- Correlation of CheY-P concentration and motor behavior during attractant adaptation in singleScience advances · 2026Article
- The dynamic response of the bacterial flagellar motor to its direct intracellular input signal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Signature of cooperativity in the stochastic fluctuations of small systems with application to the bacterial flagellar motor.Scientific reports · 2025Article
- Article
- Scrutinizing Stator Rotation in the Bacterial Flagellum: Reconciling Experiments and Switching Models.Biomolecules · 2025Review
- Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration inAnnual review of chemical and biomolecular engineering · 2024Review
- Article
- Structure, Assembly, and Function of Flagella Responsible for Bacterial Locomotion.EcoSal Plus · 2023Review
- Real-Time Deduction of Mechanisms and Kinetics Underlying Photocatalytic Water Disinfection: Cell Motility and Particle Tracking.ACS ES&T water · 2023Article
- Article
- The Effect of the Second Messenger c-di-GMP on Bacterial Chemotaxis in Escherichia coli.Applied and environmental microbiology · 2022Article
- Article
- Bacterial motility: machinery and mechanisms.Nature reviews. Microbiology · 2022Review
- Bacterial Proprioception: Can a Bacterium Sense Its Movement?Frontiers in microbiology · 2022Review
- Structural basis of bacterial flagellar motor rotation and switching.Trends in microbiology · 2021Review
- Mechanosensitive recruitment of stator units promotes binding of the response regulator CheY-P to the flagellar motor.Nature communications · 2021Article
- Asymmetric random walks reveal that the chemotaxis network modulates flagellar rotational bias ineLife · 2021Article
- Architecture and Assembly of the Bacterial Flagellar Motor Complex.Sub-cellular biochemistry · 2021Review
- Construction and Loss of Bacterial Flagellar Filaments.Biomolecules · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The bacterial flagellar motor has been shown in previous work to adapt to changes in the steady-state concentration of the chemotaxis signaling molecule, CheY-P, by changing the FliM content. We show here that the number of FliM molecules in the motor and the fraction of FliM molecules that exchange depend on the direction of flagellar rotation, not on CheY-P binding per se. Our results are consistent with a model in which the structural differences associated with the direction of rotation modulate the strength of FliM binding. When the motor spins counterclockwise, FliM binding strengthens, the fraction of FliM molecules that exchanges decreases, and the ring content increases. The larger number of CheY-P binding sites enhances the motor's sensitivity, i.e., the motor adapts. An interesting unresolved question is how additional copies of FliM might be accommodated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.