ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012
Effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low-income women with breast cancer.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
108 citing papers in PubMed, 6 syntheses or guidelines pooled it, 207 citations in OpenAlex.
- Breast cancer survival in Ethiopia: a systematic review and meta-analysis of rates and predictors.Cancer causes & control : CCC · 2025Pooled it
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Racial disparities in chemotherapy administration for early-stage breast cancer: a systematic review and meta-analysis.Breast cancer research and treatment · 2018Pooled it
- The impact of patient navigation on the delivery of diagnostic breast cancer care in the National Patient Navigation Research Program: a prospective meta-analysis.Breast cancer research and treatment · 2016Pooled it
- Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review.British journal of cancer · 2015Pooled it
- Impact of patient navigation on timely cancer care: the Patient Navigation Research Program.Journal of the National Cancer Institute · 2014Pooled it
- Patient navigation to address sociolegal barriers for patients with cancer: A comparative-effectiveness study.Cancer · 2022Trial
- Characteristics of the Delayed or Refusal Therapy in Breast Cancer Patients: A Longitudinal Population-Based Study in Taiwan.PloS one · 2015Trial
- Can patient navigation improve receipt of recommended breast cancer care? Evidence from the National Patient Navigation Research Program.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Trial
- Trial
- Racial disparities and utilization trends of first-line targeted therapies for metastatic breast cancer.JNCI cancer spectrum · 2026Article
- Health economic analysis of organizational models for breast cancer surgery: a bottom-up micro-costing and cost-minimization approach.Health economics review · 2026Article
- Delay in breast cancer surgery: evaluating patient, healthcare access, and social vulnerability predictors.Cancer causes & control : CCC · 2026Article
- Time to treatment initiation and overall survival in osteosarcoma: a national cancer database analysis.Bone & joint open · 2026Article
- Navigation program: comparison of diagnosis-treatment times among breast cancer patients.Revista latino-americana de enfermagem · 2026Article
- Diagnostic delays, treatment timeliness, and patient experiences in triple-negative breast cancer: a mixed-methods study.Frontiers in oncology · 2026Article
- Factors Influencing Time to Treatment Initiation for Breast Cancer in Ethiopia.Cancer medicine · 2025Article
- Determinants of delay in presentation to completion of treatment in cervical cancer.Scientific reports · 2025Observational
- Developing a real-time registry to track breast cancer patients across the city of Boston.JAMIA open · 2025Article
- Patient-Reported Barriers to Healthcare Access Among Patients with Gastrointestinal Cancer: Insights from 45,000 Participants in the All of Us Research Program.Research square · 2025Article
48 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine the impact of longer periods between biopsy-confirmed breast cancer diagnosis and the initiation of treatment (Dx2Tx) on survival. PATIENTS AND
methodsThis study was a noninterventional, retrospective analysis of adult female North Carolina Medicaid enrollees diagnosed with breast cancer from January 1, 2000, through December, 31, 2002, in the linked North Carolina Central Cancer Registry-Medicaid Claims database. Follow-up data were available through July 31, 2006. Cox proportional hazards regression models were constructed to evaluate the impact on survival of delaying treatment ≥ 60 days after a confirmed diagnosis of breast cancer.
resultsThe study cohort consisted of 1,786 low-income, adult women with a mean age of 61.6 years. A large proportion of the patients (44.3%) were racial minorities. Median time from biopsy-confirmed diagnosis to treatment initiation was 22 days. Adjusted Cox proportional hazards regression showed that although Dx2Tx length did not affect survival among those diagnosed at early stage, among late-stage patients, intervals between diagnosis and first treatment ≥ 60 days were associated with significantly worse overall survival (hazard ratio [HR], 1.66; 95% CI, 1.00 to 2.77; P = .05) and breast cancer-specific survival (HR, 1.85; 95% CI, 1.04 to 3.27; P = .04).
conclusionOne in 10 women waited ≥ 60 days to initiate treatment after a diagnosis of breast cancer. Waiting ≥ 60 days to initiate treatment was associated with a significant 66% and 85% increased risk of overall and breast cancer-related death, respectively, among late-stage patients. Interventions designed to increase the timeliness of receiving breast cancer treatments should target late-stage patients, and clinicians should strive to promptly triage and initiate treatment for patients diagnosed at late stage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.