ArticleThe Prostate2013
Clinical-pathologic correlation between transperineal mapping biopsies of the prostate and three-dimensional reconstruction of prostatectomy specimens.
Article in The Prostate, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prostate MRI, with or without MRI-targeted biopsy, and systematic biopsy for detecting prostate cancer.The Cochrane database of systematic reviews · 2019Pooled it
- Accuracy of the magnetic resonance imaging pathway in the detection of prostate cancer: a systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2019Pooled it
- The role of focal therapy in the management of localised prostate cancer: a systematic review.European urology · 2014Pooled it
- Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy.European urology · 2022Trial
- The concordance between the volume hotspot and the grade hotspot: a 3-D reconstructive model using the pathology outputs from the PROMIS trial.Prostate cancer and prostatic diseases · 2016Trial
- Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial.BMC cancer · 2016Trial
- Active Surveillance Outcomes After Template-Guided Mapping Biopsy Among Patients With Prostate Cancer.JAMA network open · 2026Article
- Method to determine the nadir PSA following partial gland ablation.BJUI compass · 2025Article
- Utility of transperineal template-guided mapping prostate biopsy in biopsy-naïve men with PI-RADS 1-2 on multiparametric magnetic resonance imaging.Prostate international · 2024Article
- BioPrev-C - development and validation of a contemporary prostate cancer risk calculator.Frontiers in oncology · 2024Article
- Review
- Article
- Transperineal prostate biopsy identifies locations of clinically significant prostate cancer in men considering focal therapy with PI-RADS 3-5 regions of interest.BJUI compass · 2021Article
- The impact of age on prostate cancer progression and quality of life in active surveillance patients.BJUI compass · 2021Article
- Can Prostate-Specific Antigen Density Be an Index to Distinguish Patients Who Can Omit Repeat Prostate Biopsy in Patients with Negative Magnetic Resonance Imaging?Cancer management and research · 2021Article
- Active surveillance outcomes in prostate cancer patients: the use of transperineal template-guided mapping biopsy for patient selection.World journal of urology · 2020Article
- Validation of T2- and diffusion-weighted magnetic resonance imaging for mapping intra-prostatic tumour prior to focal boost dose-escalation using intensity-modulated radiotherapy (IMRT).Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2019Article
- The clinical utility of transperineal template-guided saturation prostate biopsy for risk stratification after transrectal ultrasound-guided biopsy.Investigative and clinical urology · 2019Article
- Multi-parametric MRI zone-specific diagnostic model performance compared with experienced radiologists for detection of prostate cancer.European radiology · 2019Article
- Prostate Imaging Compared to Transperineal Ultrasound-guided biopsy for significant prostate cancer Risk Evaluation (PICTURE): a prospective cohort validating study assessing Prostate HistoScanning.Prostate cancer and prostatic diseases · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundExtended transrectal ultrasound guided biopsies (TRUSB) of the prostate may not accurately convey true morphometric information and Gleason score (GS) of prostate cancer (PCa) and the clinical use of template-guided (5-mm grid) transperineal mapping biopsies (TPMBs) remains controversial.
methodsWe correlated the clinical-pathologic results of 1,403 TPMB cores obtained from 25 men diagnosed with PCa with 64 cancer lesions found in their corresponding radical prostatectomy (RP) specimens. Special computer models of three-dimensional, whole-mounted radical prostatectomy (3D-WMRP) specimens were generated and used as gold standard to determine tumor morphometric data. Between-sample rates of upgrade and downgrade (highest GS and a novel cumulative GS) and upstage and downstage (laterality) were determined. Lesions ≥ 0.5 cm(3) or GS ≥ 7 were considered clinically significant.
resultsFrom 64 separate 3D-WMRP lesions, 25 had significant volume (mean 1.13 cm(3)) and 39 were insignificant (mean 0.09 cm(3)) (P < 0.0001); 18/64 lesions were missed by TPMB, but only one was clinically significant with GS-8 (0.02 cm(3)). When comparing the cumulative GS of TPMB versus RP, 72% (n = 18) had identical scores, 12% (n = 3) were upgraded, and only 16% (n = 4) were downgraded. Laterality of TPMB and RP was strongly correlated, 80% same laterality, 4% were up-staged, and 16% down-staged.
conclusionsOur clinical-pathology correlation showed very high accuracy of TPMB with a 5-mm grid template to detect clinically significant PCa lesions as compared with 3D-WMRP, providing physicians and patients with a reliable assessment of grade and stage of disease and the opportunity to choose the most appropriate therapeutic options.
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