ReviewBritish journal of clinical pharmacology2013
Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice.
Review in British journal of clinical pharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review.PharmacogenomicsPooled it
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- KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers.Orphanet journal of rare diseases · 2017Trial
- Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization.European journal of clinical pharmacology · 2016Trial
- [Practical management of drug-induced long QT syndrome].Innere Medizin (Heidelberg, Germany) · 2026Review
- Reevaluating Clozapine-Induced QT Prolongation.Schizophrenia bulletin · 2026Article
- Menthol-induced sedation and hemodynamic safety limits in Nile tilapia: defining a therapeutic window.Fish physiology and biochemistry · 2026Article
- The effect of oral ciprofloxacin at conventional doses on the QT interval in a tertiary outpatient setting.The Journal of antimicrobial chemotherapy · 2026Article
- Effects of Cholinesterase Inhibitor Medication on QTc Interval in Memory Clinic Patients.The Annals of pharmacotherapy · 2026Article
- Ventricular Tachycardia.Journal of education & teaching in emergency medicine · 2023Article
- Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning.Kidney research and clinical practice · 2023Article
- Unraveling Structural Alerts in Marketed Drugs for Improving Adverse Outcome Pathway Framework of Drug-Induced QT Prolongation.International journal of molecular sciences · 2023Article
- Prevalence of Potential Pharmacological Interactions in Patients Undergoing Systemic Chemotherapy in a Tertiary Hospital.Hospital pharmacy · 2022Article
- The Risk of Fatal Arrhythmias in Post-Myocardial Infarction Depression in Association With Venlafaxine.Cureus · 2022Review
- The Significance of Estimated Glomerular Filtration Rate for Predicting Mortality in Glyphosate Herbicide-Intoxicated Patients: A Single-Center, Retrospective Observational Study.Journal of clinical medicine · 2022Article
- Heart-Rate-Corrected QT Interval Response to Ramosetron during Robot-Assisted Laparoscopic Prostatectomy: A Randomized Trial.Journal of personalized medicine · 2022Article
- Estimation of cardiac QTc intervals in people prescribed antipsychotics: a comparison of correction factors.Therapeutic advances in psychopharmacology · 2022Article
- Drug-Drug Interactions in Vestibular Diseases, Clinical Problems, and Medico-Legal Implications.International journal of environmental research and public health · 2021Review
- The QT Interval and Predicting Risk in Toxicology.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2021Article
- Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age.Journal of psychopharmacology (Oxford, England) · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There has been an increasing focus on drug induced QT prolongation including research on drug development and QT prolongation, following the removal of drugs due to torsades de pointes (TdP). Although this has improved our understanding of drug-induced QT prolongation there has been much less research aimed at helping clinicians assess risk in individual patients with drug induced QT prolongation. This review will focus on assessment of drug-induced QT prolongation in clinical practice using a simple risk assessment approach. Accurate measurement of the QT interval is best done manually, and not using the measurement of standard ECG machines. Correction for heart rate (HR) using correction formulae such as Bazett's is often inaccurate. These formulae underestimate and overestimate the duration of cardiac repolarization at low and high heart rates, respectively. Numerous cut-offs have been suggested as an indicator of an abnormal QT, but are problematic in clinical practice. An alternative approach is the QT nomogram which is a plot of QT vs. HR. The nomogram has an 'at risk' line and QT-HR pairs above this line have been shown in a systematic study to be associated with TdP and the line is more sensitive and specific than Bazett's QTc of 440 ms or 500 ms. Plotting the QT-HR pair for patients on drugs suspected or known to cause QT prolongation allows assessment of the QT interval based on normal population QT variability. This risk assessment then allows the safer commencement of drugs therapeutically or management of drug induced effects in overdose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.