Evidence map›Paper›PMID 23167546›Full record

ArticleACS nano2012

Cell-specific multifunctional processing of heterogeneous cell systems in a single laser pulse treatment.

Ekaterina Y Lukianova-Hleb, Martin B G Mutonga, Dmitri O Lapotko

Abstract read
In one paragraph

Article in ACS nano, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Optical mapping and optogenetics in cardiac electrophysiology research and therapy: a state-of-the-art review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
  3. Review
  4. Advanced tools and methods for single-cell surgery.Microsystems & nanoengineering · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. All-in-one processing of heterogeneous human cell grafts for gene and cell therapy.Molecular therapy. Methods & clinical development · 2016
    Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ekaterina Y Lukianova-HlebDepartment of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Texas 77005, USA.
Martin B G Mutonga
Dmitri O Lapotko

Funding

Cell Theranostics with Tunable Plasmonic NanobubblesR01GM094816 · NIGMS · RICE UNIVERSITY · PI LAPOTKO, DMITRI · 2010 to 2013
$1.1M
Laser scanning confocal microscopeS10RR026399 · NCRR · RICE UNIVERSITY · PI BARTEL, BONNIE · 2010 to 2010
$500k
NCRR NIH HHS S10 RR026399NCRR NIH HHS S10RR026399-01NIGMS NIH HHS R01 GM094816NIGMS NIH HHS R01GM094816
6 · The paper itself

Abstract

Current methods of cell processing for gene and cell therapies use several separate procedures for gene transfer and cell separation or elimination, because no current technology can offer simultaneous multifunctional processing of specific cell subsets in highly heterogeneous cell systems. Using the cell-specific generation of plasmonic nanobubbles of different sizes around cell-targeted gold nanoshells and nanospheres, we achieved simultaneous multifunctional cell-specific processing in a rapid single 70 ps laser pulse bulk treatment of heterogeneous cell suspension. This method supported the detection of cells, delivery of external molecular cargo to one type of cells and the concomitant destruction of another type of cells without damaging other cells in suspension, and real-time guidance of the above two cellular effects.

Indexed as

LasersCell- and Tissue-Based TherapyDrug CarriersGenetic TherapyGoldHumansJurkat CellsMetal NanoparticlesParticle SizeDrug CarriersGold

Identifiers

PMID23167546
PMCPMC3528843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.