ArticleBMC microbiology2012
Effects of the Campylobacter jejuni CJIE1 prophage homologs on adherence and invasion in culture, patient symptoms, and source of infection.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Identification and characterization of an invasive, hyper-aerotolerantASM case reports · 2025Article
- The Role of Temperate Phages in Bacterial Pathogenicity.Microorganisms · 2023Review
- Genomic insights into phage-host interaction in the deep-sea chemolithoautotrophic Campylobacterota, Nitratiruptor.ISME communications · 2022Article
- Cryptic Prophages Contribution forMicroorganisms · 2022Article
- Application of Bacteriophages to LimitFrontiers in microbiology · 2021Review
- Campylobacter bacteriophage DA10: an excised temperate bacteriophage targeted by CRISPR-cas.BMC genomics · 2020Article
- Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016.Emerging infectious diseases · 2019Article
- The food-borne pathogen Campylobacter jejuni responds to the bile salt deoxycholate with countermeasures to reactive oxygen species.Scientific reports · 2017Article
- Antioxidant activity and influence ofFood science and biotechnology · 2017Article
- Genomic insights from whole genome sequencing of four clonal outbreak Campylobacter jejuni assessed within the global C. jejuni population.BMC genomics · 2016Article
- The CJIE1 prophage of Campylobacter jejuni affects protein expression in growth media with and without bile salts.BMC microbiology · 2014Article
- DNA sequence heterogeneity of Campylobacter jejuni CJIE4 prophages and expression of prophage genes.PloS one · 2014Article
- Transmigration route of Campylobacter jejuni across polarized intestinal epithelial cells: paracellular, transcellular or both?Cell communication and signaling : CCS · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProphages of enteric bacteria are frequently of key importance for the biology, virulence, or host adaptation of their host. Some C. jejuni isolates carry homologs of the CJIE1 (CMLP 1) prophage that carry cargo genes potentially involved in virulence. Possible role(s) of CJIE1 homologs in the biology and virulence of C. jejuni were therefore investigated by using in vitro cell culture assays and by assessing the association of C. jejuni isolates with and without these prophages with patients' symptoms, with source, and with clonal lineages within the C. jejuni population.
resultsFour C. jejuni isolates, three carrying the CJIE1-like prophage and one without, were tested in cell culture assays for adherence and invasion. Both adherence and invasion of C. jejuni to cells in culture were increased by the presence of the CJIE1-family prophage. Differences in motility and growth rate did not appear to be responsible. The CJIE1 prophage was present in 23% of isolates from human and non-human sources combined that were obtained through sentinel-site surveillance, and the distribution of CJIE1 in this population showed modest clonal associations. There was no correlation between the presence of the CJIE1 prophage in C. jejuni and patient symptoms, although there was some statistical support for lower rates of abdominal pain and fever when the prophage was present. Little evidence was found for a role of the prophage in host adaptation or host specificity.
conclusionThese biological effects suggest that the presence of the prophage may be a marker for differential virulence of some C. jejuni isolates. Ongoing research into the effects of the prophage on protein expression may provide additional insights into the roles the prophage may play in the biology of its host bacterium.
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