ArticlePloS one2012
A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 85 citations in OpenAlex.
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- A conserved structural framework accompanies evolutionary divergence and expression specialization in the grapevine SKP1 family.Frontiers in plant science · 2026Article
- Analysis of Genetic Variation of Rice Straw Characteristics and Its Influence on Biomass.Plant direct · 2026Article
- Dynamic ASK1 proximity networks uncover SCF-dependent and noncanonical roles in ABA and drought adaptation.bioRxiv : the preprint server for biology · 2025Article
- Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase-receptor-substrate complex.Nature communications · 2025Article
- Combined Bulked Segregant Analysis-Sequencing and Transcriptome Analysis to Identify Candidate Genes Associated with Cold Stress inInternational journal of molecular sciences · 2025Article
- Genome-Wide Identification and Functional Characterization ofInternational journal of molecular sciences · 2025Article
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- TurboID-based proteomic profiling reveals proxitome of ASK1 and CUL1 of the SCF ubiquitin ligase in plants.The New phytologist · 2024Article
- Genome-Wide Network Analysis of Above- and Below-Ground Co-growth inPlant phenomics (Washington, D.C.) · 2024Article
- Identification and Expression Analysis of theInternational journal of molecular sciences · 2023Article
- F-box receptor mediated control of substrate stability and subcellular location organizes cellular development of Aspergillus nidulans.PLoS genetics · 2022Article
- Genetic Determinants of Fiber-Associated Traits in Flax Identified by Omics Data Integration.International journal of molecular sciences · 2022Article
- A small chromosomal inversion mediated by MITE transposons confers cleistogamy in Brassica napus.Plant physiology · 2022Article
- Constitutive expression of a pea apyrase, psNTP9, increases seed yield in field-grown soybean.Scientific reports · 2022Article
- A common F-box gene regulates the leucine homeostasis of Medicago truncatula and Arabidopsis thaliana.Protoplasma · 2022Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
F-Box (FBX) proteins are encoded by a multigene family present in major lineages of eukaryotes. A number of FBX proteins are shown to be subunits of SCF complex, a type of E3 ligases composed of SKP1, CULLIN, FBX and RBX1 proteins. The Arabidopsis SKP-LIKE (ASK) proteins are also members of a family and some of them interact with FBX proteins directly. To clarify how FBX and ASK proteins combine, we carried out a large-scale interaction analysis between FBX and ASK proteins using yeast two-hybrid assay (Y2H) in Arabidopsis thaliana. FBX proteins randomly chosen from those proteins that interacted with more than one ASK protein were further analyzed for their subcellular localization and in vivo interaction with ASK proteins. Furthermore, the expression profiles of FBX and ASK genes were compared. This work reveals that FBX proteins had a preference for interacting with ASK proteins depending on the domains they contain such as the FBX-associated (FBA) domain, the Kelch domain and leucine rich repeat (LRR). In addition, it was found that a single FBX protein could form multiple SCF complexes by interacting with several ASK proteins in many cases. Furthermore, it was suggested that the variation of SCF complexes were especially abundant in tissues related to male gametophyte and seed development. More than half of the FBX proteins studied did not interact with any of the ASK proteins, implying the necessity for certain regulations for their interaction in vivo and/or distinct roles from subunits of the SCF complex.
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