ArticlePloS one2012
MR neurography in ulnar neuropathy as surrogate parameter for the presence of disseminated neuropathy.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Six-month periodic fasting does not affect somatosensory nerve function in type 2 diabetes patients.Frontiers in endocrinology · 2023Trial
- Thoracic outlet syndrome in 3T MR neurography-fibrous bands causing discernible lesions of the lower brachial plexus.European radiology · 2014Trial
- Assessment of Motor Function in Peripheral Nerve Injury and Recovery.Orthopedic reviews · 2022Article
- Magnetic Resonance Neurography for Evaluation of Peripheral Nerves.Journal of brachial plexus and peripheral nerve injury · 2021Review
- [Entrapment and non-entrapment syndromes at the elbow].Der Radiologe · 2018Review
- Novel pathomechanisms in inflammatory neuropathies.Journal of neuroinflammation · 2017Review
- [Clinical indications for high-resolution MRI diagnostics of the peripheral nervous system].Der Radiologe · 2017Review
- [Diagnostic criteria in MR neurography].Der Radiologe · 2017Review
- Posterior interosseous neuropathy: Supinator syndrome vs fascicular radial neuropathy.Neurology · 2016Article
- Clinical impact of magnetic resonance neurography in patients with brachial plexus neuropathies.The British journal of radiology · 2016Article
- MR Neurography: Diagnostic Imaging in the PNS.Clinical neuroradiology · 2015Article
- Diagnostic signs of motor neuropathy in MR neurography: nerve lesions and muscle denervation.European radiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with ulnar neuropathy of unclear etiology occasionally present with lesion extension from elbow to upper arm level on MRI. This study investigated whether MRI thereby distinguishes multifocal neuropathy from focal-compressive neuropathy at the elbow.
methodsThis prospective study was approved by the institutional ethics committee and written informed consent was obtained from all participants. 122 patients with ulnar mononeuropathy of undetermined localization and etiology by clinical and electrophysiological examination were assessed by MRI at upper arm and elbow level using T2-weighted fat-saturated sequences at 3T. Twenty-one patients were identified with proximal ulnar nerve lesions and evaluated for findings suggestive of disseminated neuropathy (i) subclinical lesions in other nerves, (ii) unfavorable outcome after previous decompressive elbow surgery, and (iii) subsequent diagnosis of inflammatory or other disseminated neuropathy. Two groups served as controls for quantitative analysis of nerve-to-muscle signal intensity ratios: 20 subjects with typical focal ulnar neuropathy at the elbow and 20 healthy subjects.
resultsIn the group of 21 patients with proximal ulnar nerve lesion extension, T2-w ulnar nerve signal was significantly (p<0.001) higher at upper arm level than in both control groups. A cut-off value of 1.92 for maximum nerve-to-muscle signal intensity ratio was found to be sensitive (86%) and specific (100%) to discriminate this group. Ten patients (48%) exhibited additional T2-w lesions in the median and/or radial nerve. Another ten (48%) had previously undergone elbow surgery without satisfying outcome. Clinical follow-up was available in 15 (71%) and revealed definitive diagnoses of multifocal neuropathy of various etiologies in four patients. In another eight, diagnoses could not yet be considered definitive but were consistent with multifocal neuropathy.
conclusionProximal ulnar nerve T2 lesions at upper arm level are detected by MRI and indicate the presence of a non-focal disseminated neuropathy instead of a focal compressive neuropathy.
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