ArticlePloS one2012
Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis.Bioscience reports · 2019Pooled it
- Genetic polymorphisms of IL-17A rs2275913, rs3748067 and IL-17F rs763780 in gastric cancer risk: evidence from 8124 cases and 9873 controls.Molecular biology reports · 2018Pooled it
- Pooled it
- Association between the PARP1 Val762Ala polymorphism and cancer risk: evidence from 43 studies.PloS one · 2014Pooled it
- Polymorphisms in the ERCC1 and XPF genes and risk of breast cancer in a Chinese population.Genetic testing and molecular biomarkers · 2013Trial
- The link of ERCC2 rs13181 and ERCC4 rs2276466 polymorphisms with breast cancer in the Bangladeshi population.Molecular biology reports · 2022Article
- Genetic Variations in Nucleotide Excision Repair Pathway Genes and Risk of Allergic Rhinitis.Mediators of inflammation · 2022Article
- Distribution and susceptibility of ERCC1/XPF gene polymorphisms in Han and Uygur women with breast cancer in Xinjiang, China.Cancer medicine · 2020Article
- Function and Interactions of ERCC1-XPF in DNA Damage Response.Molecules (Basel, Switzerland) · 2018Review
- Functional Polymorphisms at ERCC1/XPF Genes Confer Neuroblastoma Risk in Chinese Children.EBioMedicine · 2018Article
- Genetic variants in the nucleotide excision repair pathway genes and gastric cancer susceptibility in a southern Chinese population.Cancer management and research · 2018Article
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- Article
- LMO1 gene polymorphisms contribute to decreased neuroblastoma susceptibility in a Southern Chinese population.Oncotarget · 2016Article
- Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.Oncotarget · 2016Article
- PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.Oncotarget · 2016Article
- Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks.Oncotarget · 2016Article
- Polymorphisms in the XPC gene and gastric cancer susceptibility in a Southern Chinese population.OncoTargets and therapy · 2016Article
- Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population.Oncotarget · 2015Article
- Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery.Oncotarget · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk.
methodsThree ERCC1 functional SNPs (rs2298881C>A, rs3212986C>A and rs11615G>A) and two XPF/ERCC4 functional SNPs (rs2276466C>G and rs6498486A>C) were genotyped for 1125 gastric adenocarcinoma cases and 1196 cancer-free controls by Taqman assays. Odds ratios (OR) and 95% confidence intervals (CI) were used to estimate risk associations, and false-positive report probabilities (FPRP) were calculated for assessing significant findings.
resultsERCC1 rs2298881C and rs11615A variant genotypes were associated with increased gastric cancer risk (adjusted OR=1.33, 95% CI=1.05-1.67 for rs2298881 AC/CC and adjusted OR=1.23, 95% CI=1.05-1.46 for rs11615 AG/AA, compared with their common genotype AA and GG, respectively). Patients with 2-3 ERCC1 risk genotypes had significant increased risk (adjusted OR=1.56, 95% CI=1.27-1.93), compared with those with 0-1 ERCC1 risk genotypes, and this risk was more significantly in subgroups of never drinkers, non-gastric cardia adenocarcinoma (NGCA) and clinical stage I+II. All these risks were not observed for XPF SNPs.
conclusionsThese findings suggest that functional ERCC1 SNPs may contribute to risk of gastric cancer. Larger and well-designed studies with different ethnic populations are needed to validate our findings.
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