ArticlePLoS computational biology2012
Chemotactic migration of T cells towards dendritic cells promotes the detection of rare antigens.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Decoding cellular population dynamics through mechanistic modelling and statistical data analysis.NPJ systems biology and applications · 2026Review
- Liver sinusoid constraints make random search of CD8 T cells for Plasmodium parasites efficient.bioRxiv : the preprint server for biology · 2025Article
- Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.Frontiers in immunology · 2024Article
- New tools for immunologists: models of lymph node function from cells to tissues.Frontiers in immunology · 2023Review
- Density-Dependent Migration Characteristics of Cancer Cells Driven by Pseudopod Interaction.Frontiers in cell and developmental biology · 2022Article
- Review
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- T cell migration in microchannels densely packed with T cells.Scientific reports · 2019Article
- Role of T Cell-To-Dendritic Cell Chemoattraction in T Cell Priming Initiation in the Lymph Node: An Agent-Based Modeling Study.Frontiers in immunology · 2019Article
- Spatial Lymphocyte Dynamics in Lymph Nodes Predicts the Cytotoxic T Cell Frequency Needed for HIV Infection Control.Frontiers in immunology · 2019Article
- A virtual lymph node model to dissect the requirements for T-cell activation by synapses and kinapses.Immunology and cell biology · 2016Article
- A spatial model of the efficiency of T cell search in the influenza-infected lung.Journal of theoretical biology · 2016Article
- In vivo confinement promotes collective migration of neural crest cells.The Journal of cell biology · 2016Article
- Mathematics in modern immunology.Interface focus · 2016Review
- Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes.Lymphatic research and biology · 2015Article
- CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance.The Journal of experimental medicine · 2015Article
- How is the effectiveness of immune surveillance impacted by the spatial distribution of spreading infections?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Heterogeneous CD8+ T cell migration in the lymph node in the absence of inflammation revealed by quantitative migration analysis.PLoS computational biology · 2015Article
- Three-dimensional numerical model of cell morphology during migration in multi-signaling substrates.PloS one · 2015Article
- Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
In many immunological processes chemoattraction is thought to play a role in guiding cells to their sites of action. However, based on in vivo two-photon microscopy experiments in the absence of cognate antigen, T cell migration in lymph nodes (LNs) has been roughly described as a random walk. Although it has been shown that dendritic cells (DCs) carrying cognate antigen in some circumstances attract T cells chemotactically, it is currently still unclear whether chemoattraction of T cells towards DCs helps or hampers scanning. Chemoattraction towards DCs could on the one hand help T cells to rapidly find DCs. On the other hand, it could be deleterious if DCs become shielded by a multitude of attracted yet non-specific T cells. Results from a recent simulation study suggested that the deleterious effect dominates. We re-addressed the question whether T cell chemoattraction towards DCs is expected to promote or hamper the detection of rare antigens using the Cellular Potts Model, a formalism that allows for dynamic, flexible cellular shapes and cell migration. Our simulations show that chemoattraction of T cells enhances the DC scanning efficiency, leading to an increased probability that rare antigen-specific T cells find DCs carrying cognate antigen. Desensitization of T cells after contact with a DC further improves the scanning efficiency, yielding an almost threefold enhancement compared to random migration. Moreover, the chemotaxis-driven migration still roughly appears as a random walk, hence fine-tuned analysis of cell tracks will be required to detect chemotaxis within microscopy data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.