ArticleJournal of Korean medical science2012
Successful treatment of primary central nervous system lymphoma without irradiation in children: single center experience.
Article in Journal of Korean medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- [Clinical study of 15 cases of primary non-immunodeficient central nervous system lymphoma in children].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Primary Central Nervous System Burkitt Lymphoma, Presenting with Long-Term Fluctuating Level of Consciousness: A Case Report and Literature Review on Challenges in Diagnosis and Management.The American journal of case reports · 2022Review
- A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.Blood advances · 2022Article
- Primary central nervous system lymphoblastic B cell lymphoma located at cerebellum in a child: A case report and literature review.Pediatric investigation · 2021Article
- Primary central nervous system lymphoma: initial features, outcome, and late effects in 75 children and adolescents.Blood advances · 2019Article
- A rare case of paediatric primary central nervous system lymphoma treated with high-dose methotrexate and rituximab-based chemoimmunotherapy and whole brain radiotherapy followed by tumour bed boost with three-dimensional conformal radiation technique.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018Article
- Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-Old Cerebral Palsy Patient.Case reports in oncological medicine · 2018Article
- Management of primary central nervous system lymphoma in children.Hematology. American Society of Hematology. Education Program · 2016Review
- Diagnosis and treatment of primary central nervous system lymphoma: A report of nine cases and literature review.Oncology letters · 2015Article
- Autoimmune Hemolytic Anemia preceding the Diagnosis of Primary Central Nervous System Lymphoma.Iranian journal of pediatric hematology and oncology · 2015Article
- Article
- Primary burkitt lymphoma of the fourth ventricle in an immunocompetent young patient.Case reports in pathology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary CNS lymphoma (PCNSL) is a very uncommon disease in children, and usually treated by chemotherapy, combined with focal or craniospinal radiotherapy (RT). However, adverse effects of RT are a concern. We evaluated the outcomes of childhood PCNSL, treated with systemic and intrathecal chemotherapy, but without RT. For fifteen years, six patients among 175 of non-Hodgkin lymphoma were diagnosed as PCNSL in Seoul National University Children's Hospital and we analyzed their medical records retrospectively. Their male:female ratio was 5:1, and median age was 10.1 yr. The primary sites were the sellar area in three patients, parietal area in one, cerebellum in one, and multiple areas in one. Their pathologic diagnoses were diffuse large B-cell lymphoma in three patients, Burkitt lymphoma in two, and undifferentiated B-cell lymphoma in one. Five were treated with the LMB96 treatment protocol, and one was treated with the CCG-106B protocol. None had RT as a first-line treatment. One patient had a local relapse and received RT and salvage chemotherapy, without success. No patient had treatment-related mortality. Their estimated 5-yr event-free and overall survival rates were both 83.3%. In conclusion, PCNSL is a rare disease in childhood, but successfully treated by chemotherapy without RT.
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