ArticleJournal of Korean medical science2012
Phylogenetic analysis of the 56-kDa type-specific protein genes of Orientia tsutsugamushi in Central Korea.
Article in Journal of Korean medical science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Case Report: An imported severe case of paediatric scrub typhus with Karp B subgenotype in non-endemic Northern China, Beijing.Frontiers in pediatrics · 2026Article
- Molecular Epidemiology and Genetic Diversity of Orientia tsutsugamushi From Patients and Small Mammals in Xiangyun County, Yunnan Province, China.Veterinary medicine and science · 2025Article
- Phylogenetic and immunological investigations of complete TSA56 ORF of Orientia tsutsugamushi present in acute encephalitis syndrome cases from eastern Uttar Pradesh, India.Archives of microbiology · 2023Article
- Molecular epidemiology of scrub typhus in Taiwan during 2006-2016.PLoS neglected tropical diseases · 2022Article
- Diagnosis of scrub typhus: recent advancements and challenges.3 Biotech · 2020Review
- Clinical characteristics of acute Q fever patients in South Korea and time from symptom onset to serologic diagnosis.BMC infectious diseases · 2019Article
- Molecular Epidemiology of anThe American journal of tropical medicine and hygiene · 2018Article
- A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow.Tropical medicine and infectious disease · 2018Review
- Imported scrub typhus: first case in South America and review of the literature.Tropical diseases, travel medicine and vaccines · 2018Article
- Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka.BMC infectious diseases · 2017Article
- Unusual genotypic distribution of Orientia tsutsugamushi strains causing human infections on Jeju Island.The American journal of tropical medicine and hygiene · 2014Article
- High In Vitro Infectivity of a Doxycycline-Insensitive Strain of Orientia tsutsugamushi.Infection & chemotherapy · 2013Article
- Inappropriateness of quinolone in scrub typhus treatment due to gyrA mutation in Orientia tsutsugamushi Boryong strain.Journal of Korean medical science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are several antigenic variants of Orientia tsutsugamushi. The 56-kDa type-specific antigen (TSA) is responsible for the antigenic variation. Nucleotide sequences of the 56-kDa TSA obtained from 44 eschar samples of Korean scrub typhus patients and from 40 representative strains retrieved from the GenBank database were analyzed phylogenetically. Clinical patient data were assessed based on the genotyping results. Of the 44 nucleotide sequences, 32 (72.7%) clustered with the Boryong genotype, which is the major genotype in Korea. Eleven nucleotide sequences (25%) clustered with the Kawasaki genotype, not identified in Korea until 2010. One nucleotide sequence was consistent with the Karp genotype. The clinical course of the patients infected with each genotype showed no differences. Diagnostic performance of the immunofluorescence assay (IFA) using the 56-kDa TSA from Gilliam, Karp and Boryong as test antigens were not different for the Boryong and Kawasaki genotypes. Although Boryong is still the predominant genotype, the results suggest that Kawasaki genotype is quite prevalent in Chungbuk province of Korea.
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