ArticleNucleic acids research2013
Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 58 citations in OpenAlex.
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- Small RNAs in Cnidaria: A review.Evolutionary applications · 2023Article
- siRNA-mediated gene knockdown via electroporation in hydrozoan jellyfish embryos.Scientific reports · 2022Article
- Genome of the sea anemoneFrontiers in cell and developmental biology · 2022Article
- An Emerging Frontier in Intercellular Communication: Extracellular Vesicles in Regeneration.Frontiers in cell and developmental biology · 2022Review
- Coordinated Gene Expression and Chromatin Regulation during Hydra Head Regeneration.Genome biology and evolution · 2021Article
- Cellular, Metabolic, and Developmental Dimensions of Whole-Body Regeneration inCold Spring Harbor perspectives in biology · 2021Review
- Comprehensive annotation and characterization of planarian tRNA and tRNA-derived fragments (tRFs).RNA (New York, N.Y.) · 2021Article
- Conservation and turnover of miRNAs and their highly complementary targets in early branching animals.Proceedings. Biological sciences · 2021Article
- Epigenetic Regulation inFrontiers in cell and developmental biology · 2021Review
- The Biogenesis and Functions of piRNAs in Human Diseases.Molecular therapy. Nucleic acids · 2020Review
- The novel microRNAs hsa-miR-nov7 and hsa-miR-nov3 are over-expressed in locally advanced breast cancer.PloS one · 2020Article
- Isolation and Transcriptomic Profiling of Single Myofibers from Mice.Bio-protocol · 2019Article
- Diverse RNA interference strategies in early-branching metazoans.BMC evolutionary biology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Small non-coding RNAs such as miRNAs, piRNAs and endo-siRNAs fine-tune gene expression through post-transcriptional regulation, modulating important processes in development, differentiation, homeostasis and regeneration. Using deep sequencing, we have profiled small non-coding RNAs in Hydra magnipapillata and investigated changes in small RNA expression pattern during head regeneration. Our results reveal a unique repertoire of small RNAs in hydra. We have identified 126 miRNA loci; 123 of these miRNAs are unique to hydra. Less than 50% are conserved across two different strains of Hydra vulgaris tested in this study, indicating a highly diverse nature of hydra miRNAs in contrast to bilaterian miRNAs. We also identified siRNAs derived from precursors with perfect stem-loop structure and that arise from inverted repeats. piRNAs were the most abundant small RNAs in hydra, mapping to transposable elements, the annotated transcriptome and unique non-coding regions on the genome. piRNAs that map to transposable elements and the annotated transcriptome display a ping-pong signature. Further, we have identified several miRNAs and piRNAs whose expression is regulated during hydra head regeneration. Our study defines different classes of small RNAs in this cnidarian model system, which may play a role in orchestrating gene expression essential for hydra regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.