ArticleThe American journal of tropical medicine and hygiene2013
Alterations in Plasmodium falciparum genetic structure two years after increased malaria control efforts in western Kenya.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Genetic diversity, population structure, and drug resistance of Plasmodium falciparum in Kenya: a systematic review and meta-analysis.Malaria journal · 2025Pooled it
- Pooled it
- Assessing Microsatellite Variations in Plasmodium falciparum Following a Decade-Long Antimalaria Campaign in Kenya.Molecular ecology · 2025Article
- Temporal changes in Plasmodium falciparum genetic diversity and multiplicity of infection across three areas of varying malaria transmission intensities in Uganda.Tropical medicine and health · 2024Article
- Exploring how space, time, and sampling impact our ability to measure genetic structure acrossFrontiers in epidemiology · 2023Article
- Genomic miscellany and allelic frequencies of Plasmodium falciparum msp-1, msp-2 and glurp in parasite isolates.PloS one · 2022Article
- Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea.Molecular ecology · 2020Article
- Genetic diversity of the msp-1, msp-2, and glurp genes of Plasmodium falciparum isolates in Northwest Ethiopia.Malaria journal · 2018Article
- Impacts of Antimalarial Drugs onThe American journal of tropical medicine and hygiene · 2018Article
- Genetic Diversity of theThe American journal of tropical medicine and hygiene · 2018Article
- Emerging implications of policies on malaria treatment: genetic changes in theBMJ global health · 2018Article
- Genetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum Parasites.PloS one · 2016Article
- Genetic Diversity of Plasmodium falciparum Populations in Malaria Declining Areas of Sabah, East Malaysia.PloS one · 2016Article
- The effect of local variation in malaria transmission on the prevalence of sulfadoxine-pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi.Malaria journal · 2015Article
- Population genetics analysis during the elimination process of Plasmodium falciparum in Djibouti.Malaria journal · 2013Article
- A cohort study of Plasmodium falciparum infection dynamics in Western Kenya Highlands.BMC infectious diseases · 2010Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
The impact of malaria intervention measures (insecticide-treated net use and artemisinin combination therapy) on malaria genetics was investigated at two sites in western Kenya: an endemic lowland and an epidemic highland. The genetic structure of the parasite population was assessed by using microsatellites, and the prevalence of drug-resistant mutations was examined by using the polymerase chain reaction-restriction fragment length polymorphism method. Two years after intervention, genetic diversity remained high in both populations. A significant decrease in the prevalence of quintuple mutations conferring resistance to sulfadoxine-pyrimethamine was detected in both populations, but the mutation prevalence at codon 1246 of the Plasmodium falciparum multidrug resistance 1 gene had increased in the highland population. The decrease in sulfadoxine-pyrimethamine-resistant mutants is encouraging, but the increase in P. falciparum multidrug resistance 1 gene mutations is worrisome because these mutations are linked to resistance to other antimalarial drugs. In addition, the high level of genetic diversity observed after intervention suggests transmission is still high in each population.
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