Evidence map›Paper›PMID 23166049›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2013

Evaluation of cell function upon nanovector internalization.

Jonathan O Martinez, Alessandro Parodi, Xuewu Liu, Mikhail G Kolonin, Mauro Ferrari, Ennio Tasciotti

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Degradation and biocompatibility of multistage nanovectors in physiological systems.Journal of biomedical materials research. Part A · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan O MartinezDepartment of Nanomedicine, The Methodist Hospital Research Institute, 6670 Bertner Ave. MS R7-414 Houston, TX 77030, USA.
Alessandro Parodi
Xuewu Liu
Mikhail G Kolonin
Mauro Ferrari
Ennio Tasciotti

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Center for Clinical and Translational SciencesTL1RR024147 · NCRR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2006 to 2011
$2.3M
Stem Cell-Directed Nanotheranostics for Cancer InterventionF31CA154119 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MARTINEZ, JONATHAN OTTO · 2011 to 2014
$64k
NCI NIH HHS 1F31CA154119-01A1NCI NIH HHS CA-016672NCI NIH HHS F31 CA154119NCI NIH HHS P30 CA016672NCRR NIH HHS TL1 RR024147NCRR NIH HHS TL1RR024147
6 · The paper itself

Abstract

In vitro toxicity assays based on the evaluation and retention of advanced and specific cellular functions are proposed to investigate mesoporous silicon nanovectors. This approach provides greater insight compared to simple cellular viability and toxicity assays. Electron microscopy images demonstrate internalized nanovectors altering the curvature of the nuclear envelope with minimal effect on viability or biological function.

Indexed as

Cell SurvivalEndocytosisNanoparticlesCells, CulturedHumans

Identifiers

PMID23166049
PMCPMC3733230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.