ArticleAutism research : official journal of the International Society for Autism Research2013
Neonatal brainstem function and 4-month arousal-modulated attention are jointly associated with autism.
Article in Autism research : official journal of the International Society for Autism Research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Click-evoked auditory brainstem responses and autism spectrum disorder: a meta-analytic investigation of disorder specificity.Pediatric research · 2022Pooled it
- A Systematic Review of Brainstem Contributions to Autism Spectrum Disorder.Frontiers in integrative neuroscience · 2021Pooled it
- Click-evoked auditory brainstem responses and autism spectrum disorder: A meta-analytic review.Autism research : official journal of the International Society for Autism Research · 2018Pooled it
- Auditory brainstem response in infants and children with autism spectrum disorder: A meta-analysis of wave V.Autism research : official journal of the International Society for Autism Research · 2018Pooled it
- Prematurity and autism: a dose-response relationship across gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Caregiver report of infant behavior associated with autism likelihood in first year of life.Pediatric research · 2025Article
- Transgenerational Effects and Heritability of Folate Receptor Alpha Autoantibodies in Autism Spectrum Disorder.International journal of molecular sciences · 2025Article
- Early neurophysiological markers of aberrant auditory processing associated with increased risk of autism spectrum disorder: A systematic review.Pediatric investigation · 2025Review
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Exploring early life social and executive function development in infants and risk for autism: a prospective cohort study protocol of NICU graduates and infants at risk for cerebral palsy.BMC psychiatry · 2024Article
- Pre-autism: What a paediatrician should know about early diagnosis of autism.World journal of clinical pediatrics · 2023Review
- Auditory Cortex Maturation and Language Development in Children with Hearing Loss and Additional Disabilities.Children (Basel, Switzerland) · 2023Article
- Newborn Auditory Brainstem Responses in Children with Developmental Disabilities.Journal of autism and developmental disorders · 2023Article
- Sensitivity to interaural level and time differences in individuals with autism spectrum disorder.Scientific reports · 2022Article
- Pupil-Linked Arousal Response Reveals Aberrant Attention Regulation among Children with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Aberrant auditory system and its developmental implications for autism.Science China. Life sciences · 2021Review
- The Brainstem-Informed Autism Framework: Early Life Neurobehavioral Markers.Frontiers in integrative neuroscience · 2021Article
- Auditory brainstem responses in adults with autism spectrum disorder.Clinical neurophysiology practice · 2021Article
- Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The authors evaluated the contribution of initially abnormal neonatal auditory brainstem responses (ABRs) and 4-month arousal-modulated attention visual preference to later autism spectrum disorder (ASD) behaviors in neonatal intensive care unit (NICU) graduates. A longitudinal study design was used to compare NICU graduates with normal ABRs (n = 28) to those with initially abnormal ABRs (n = 46) that later resolved. At 4 months postterm age, visual preference (measured after feeding) for a random check pattern flashing at 1, 3, or 8 Hz and gestational age (GA) served as additional predictors. Outcome measures were PDD Behavior Inventory (PDDBI) scores at 3.4 years (standard deviation = 1.2), and developmental quotients (DQ) obtained around the same age with the Griffiths Mental Development Scales (GMDS). Preferences for higher rates of stimulation at 4 months were highly correlated with PDDBI scores (all P-values < 0.01) and the GMDS Hearing and Speech DQ, but only in those with initially abnormal ABRs. Effects were strongest for a PDDBI social competence measure most associated with a diagnosis of autism. For those with abnormal ABRs, increases in preference for higher rates of stimulation as infants were linked to nonlinear increases in severity of ASD at 3 years and to an ASD diagnosis. Abnormal ABRs were associated with later reports of repetitive and ritualistic behaviors irrespective of 4-month preference for stimulation. The joint occurrence of initially abnormal neonatal ABRs and preference for more stimulation at 4 months, both indices of early brainstem dysfunction, may be a marker for the development of autism in this cohort.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.