ArticleThe Journal of physiology2013
On-off asymmetries in oxygen consumption kinetics of single Xenopus laevis skeletal muscle fibres suggest higher-order control.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
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- Move less, spend more: the metabolic demands of short walking bouts.Proceedings. Biological sciences · 2024Article
- Methodological considerations on near-infrared spectroscopy derived muscle oxidative capacity.European journal of applied physiology · 2024Article
- How Priming Exercise Affects Oxygen Uptake Kinetics: From Underpinning Mechanisms to Endurance Performance.Sports medicine (Auckland, N.Z.) · 2023Review
- Interaction of Factors Determining Critical Power.Sports medicine (Auckland, N.Z.) · 2023Review
- Near-infrared spectroscopy estimation of combined skeletal muscle oxidative capacity and OThe Journal of physiology · 2022Article
- Physical Activity, Muscle Oxidative Capacity, and Coronary Artery Calcium in Smokers with and without COPD.International journal of chronic obstructive pulmonary disease · 2022Article
- The relationship between the time constant ofEuropean journal of applied physiology · 2021Article
- Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD.Medicine and science in sports and exercise · 2021Article
- Muscle Oxidative Capacity Is Reduced in Both Upper and Lower Limbs in COPD.Medicine and science in sports and exercise · 2020Article
- Skeletal muscle interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.Endocrine reviews · 2018Review
- Mechanisms underlying extremely fast muscle V˙OPhysiological reports · 2018Article
- Regulation of oxidative phosphorylation is different in electrically- and cortically-stimulated skeletal muscle.PloS one · 2018Article
- Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle.Journal of visualized experiments : JoVE · 2017Article
- Oxygen Uptake Kinetics Is Slower in Swimming Than Arm Cranking and Cycling during Heavy Intensity.Frontiers in physiology · 2017Article
- Reproducibility of NIRS assessment of muscle oxidative capacity in smokers with and without COPD.Respiratory physiology & neurobiology · 2017Article
- Faster and stronger manifestation of mitochondrial diseases in skeletal muscle than in heart related to cytosolic inorganic phosphate (Pi) accumulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Simultaneous sampling of tissue oxygenation and oxygen consumption in skeletal muscle.Microvascular research · 2016Article
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
Abstract
The mechanisms controlling skeletal muscle oxygen consumption (V(o)₂) during exercise are not well understood. We determined whether first-order control could explain V(o)₂kinetics at contractions onset (V(o)₂(on)) and cessation (V(o)₂off)) in single skeletal muscle fibres differing in oxdidative capacity, and across stimulation intensities up to V(o)₂(max). Xenopus laevis fibres (n = 21) were suspended in a sealed chamber with a fast response P(o)₂ electrode to measure V(o)₂ every second before, during and after stimulated isometric contractions. A first-order model did not well characterize on-transient V(o)₂ kinetics. Including a time delay (TD) in the model provided a significantly improved characterization than a first-order fit without TD (F-ratio; P < 0.05), and revealed separate 'activation' and 'exponential' phases in 15/21 fibres contracting at V(o)₂(max) (mean ± SD TD: 14 ± 3s). On-transient kinetics (τV(o)₂(on)) was weakly and linearly related to V(o)₂(max) (R² = 0.271, P = 0.015). Off-transient kinetics, however, were first-order, and τV(o)₂(off) was greater in low-oxidative (V(o)₂max < 0.05 nmol mm⁻³s⁻¹ than high-oxidative fibres (V(o)₂(max > 0.10 nmol mm ⁻³ s⁻¹; 170 ± 70 vs. 29 ± 6 s, P < 0.001). 1/ τV(o)₂(off) was proportional to V(o)₂(max) (R² = 0.727, P < 0.001), unlike in the on-transient. The calculated oxygen deficit was larger (P < 0.05) than the post-contraction volume of consumed oxygen at all intensities except V(o)₂(max). These data show a clear dissociation between the kinetic control of V(o)₂at the onset and cessation of contractions and across stimulation intensities. More complex models are therefore required to understand the activation of mitochondrial respiration in skeletal muscle at the start of exercise.
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