ArticleEnvironmental health perspectives2013
Urinary biomarkers for phthalates associated with asthma in Norwegian children.
Article in Environmental health perspectives, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal Phthalate Exposure and Allergic Diseases in Children: A Meta-Analysis and Network Toxicology.International journal of molecular sciences · 2025Pooled it
- Emerging role of microplastics and nanoplastics in children's health.Pediatric research · 2026Review
- Prenatal Exposure to Phthalates, Bisphenols and Their Mixtures and Early Childhood Allergic Conditions and Asthma: Results from the APrON Cohort.International journal of environmental research and public health · 2025Article
- Association of Childhood Asthma with the Concept of Exposomics: A Short Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Associations of environmental chemical exposures measured in personal silicone wristbands with sociodemographic factors, COVID-19 restrictions, and child respiratory health.Environmental research · 2024Article
- Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender.Archives of toxicology · 2023Article
- Phthalate Metabolites in Urine of Chinese Children and Their Association with Asthma and Allergic Symptoms.International journal of environmental research and public health · 2022Article
- Phthalate biomarkers and associations with respiratory symptoms and healthcare utilization among low-income urban children with asthma.Environmental research · 2022Article
- Are Phthalate Exposure Related to Oxidative Stress in Children and Adolescents with Asthma? A Cumulative Risk Assessment Approach.Antioxidants (Basel, Switzerland) · 2022Article
- PMEnvironmental science and pollution research international · 2022Article
- Assessment of metabolic perturbations associated with exposure to phthalates among pregnant African American women.The Science of the total environment · 2022Article
- Phthalate Esters in Tap Water, Southern Thailand: Daily Exposure and Cumulative Health Risk in Infants, Lactating Mothers, Pregnant and Nonpregnant Women.International journal of environmental research and public health · 2022Article
- Review
- Article
- Intakes of phthalates by Japanese children and the contribution of indoor air quality in their residences.Environmental science and pollution research international · 2020Article
- Multiple Stressor Effects of Radon and Phthalates in Children: Background Information and Future Research.International journal of environmental research and public health · 2020Review
- The Effects of Air Pollution on the Development of Atopic Disease.Clinical reviews in allergy & immunology · 2019Review
- Phthalates and asthma in children and adults: US NHANES 2007-2012.Environmental science and pollution research international · 2019Article
- Distribution and Dietary Predictors of Urinary Phthalate Metabolites among Pregnant Women in Shanghai, China.International journal of environmental research and public health · 2019Article
- Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study.Journal of exposure science & environmental epidemiology · 2019Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-molecular-weight phthalates in indoor dust have been associated with asthma in children, but few studies have evaluated phthalate biomarkers in association with respiratory outcomes.
objectivesWe explored the association between urinary concentrations of phthalate metabolites and current asthma.
methodsIn a cross-sectional analysis, 11 metabolites of 8 phthalates [including four metabolites of di(2-ethylhexyl) phthalate] were measured in one first morning void collected from 2001 through 2004 from 623 10-year-old Norwegian children. Logistic regression models controlling for urine specific gravity, sex, parental asthma, and income were used to estimate associations between current asthma and phthalate metabolite concentrations by quartiles or as log10-transformed variables.
resultsCurrent asthma was associated with both mono(carboxyoctyl) phthalate (MCOP) and mono(carboxynonyl) phthalate (MCNP), although the association was limited to those in the highest quartile of these chemicals. The adjusted odds ratio (aOR) for current asthma was 1.9 (95% CI: 1.0, 3.3) for the highest MCOP quartile compared with the lowest quartile, and 1.3 (95% CI: 0.98, 1.7) for an interquartile-range increase. The aOR for current asthma was 2.2 (95% CI: 1.2, 4.0) for the highest MCNP quartile and 1.3 (95% CI: 1.0, 1.7) for an interquartile-range increase. The other phthalate metabolites were not associated with current asthma.
conclusionsCurrent asthma was associated with the highest quartiles of MCOP and MCNP, metabolites of two high molecular weight phthalates, diisononyl phthalate and diisodecyl phthalate, respectively. Given the short biological half-life of the phthalates and the cross-sectional design, our findings should be interpreted cautiously.
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