ReviewThe Journal of hospital infection2013
Whole genome sequencing in the prevention and control of Staphylococcus aureus infection.
Review in The Journal of hospital infection, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Genome-Wide Resequencing Reveals Genetic Diversity and Selection Signatures in Two Indigenous Goat Populations From Xizang.Animal genetics · 2026Article
- Patterns, Associated Factors, and Anatomical Concordance of Nasal and ThroatMicroorganisms · 2026Article
- Article
- Multiple introductions of NRCS-AMicrobial genomics · 2025Article
- Genomic Insights of a Methicillin-Resistant Biofilm-ProducingBioMed research international · 2024Article
- Genomic characterization and outbreak investigations of methicillin-resistantFrontiers in microbiology · 2024Article
- Pulsed-Field Gel Electrophoresis Analysis of Bovine AssociatedPathogens (Basel, Switzerland) · 2023Review
- A 6-Year Update on the Diversity of Methicillin-ResistantFrontiers in microbiology · 2022Review
- Whole Genome Sequencing Provides an Added Value to the Investigation of Staphylococcal Food Poisoning Outbreaks.Frontiers in microbiology · 2021Article
- Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2020Review
- Prospective genomic surveillance of methicillin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Observational
- Accuracy of Different Bioinformatics Methods in Detecting Antibiotic Resistance and Virulence Factors from Staphylococcus aureus Whole-Genome Sequences.Journal of clinical microbiology · 2018Article
- Are commercial providers a viable option for clinical bacterial sequencing?Microbial genomics · 2018Article
- Intra-Hospital, Inter-Hospital and Intercontinental Spread of ST78 MRSA From Two Neonatal Intensive Care Unit Outbreaks Established Using Whole-Genome Sequencing.Frontiers in microbiology · 2018Article
- Microbiome at the Frontier of Personalized Medicine.Mayo Clinic proceedings · 2017Review
- First Complete Genome Sequence of Methicillin-ResistantGenome announcements · 2017Article
- Life After USA300: The Rise and Fall of a Superbug.The Journal of infectious diseases · 2017Review
- Bacterial Genetic Architecture of Ecological Interactions in Co-culture by GWAS-TakingFrontiers in microbiology · 2017Article
- Article
- Meningococcal vaccine antigen diversity in global databases.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2015Article
Corrections and comments
- Commented on by
Authors and funding
5 authors.
Funding
Abstract
backgroundStaphylococcus aureus remains a leading cause of hospital-acquired infection but weaknesses inherent in currently available typing methods impede effective infection prevention and control. The high resolution offered by whole genome sequencing has the potential to revolutionise our understanding and management of S. aureus infection.
aimTo outline the practicalities of whole genome sequencing and discuss how it might shape future infection control practice.
methodsWe review conventional typing methods and compare these with the potential offered by whole genome sequencing.
findingsIn contrast with conventional methods, whole genome sequencing discriminates down to single nucleotide differences and allows accurate characterisation of transmission events and outbreaks and additionally provides information about the genetic basis of phenotypic characteristics, including antibiotic susceptibility and virulence. However, translating its potential into routine practice will depend on affordability, acceptable turnaround times and on creating a reliable standardised bioinformatic infrastructure.
conclusionWhole genome sequencing has the potential to provide a universal test that facilitates outbreak investigation, enables the detection of emerging strains and predicts their clinical importance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.