Trial reportThe Journal of pediatrics2013
Randomized trial of early developmental intervention on outcomes in children after birth asphyxia in developing countries.
Trial report in The Journal of pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Effect of the Helping Babies Breathe Program on Newborn Outcomes: Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990.Pediatric research · 2013Pooled it
- Roles and effectiveness of lay community health workers in the prevention of mental, neurological and substance use disorders in low and middle income countries: a systematic review.BMC health services research · 2013Pooled it
- Home-Based Early Intervention and the Influence of Family Resources on Cognitive Development.Pediatrics · 2016Trial
- Development of a 12 month screener based on items from the Bayley II Scales of Infant Development for use in Low Middle Income countries.Early human development · 2015Trial
- Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children.BMC medicine · 2026Article
- Article
- Interventions to support the mental health of family carers of children with brain injury in low and middle income countries: a scoping review.Frontiers in rehabilitation sciences · 2024Article
- Associations between maternal metabolic conditions and neurodevelopmental conditions in offspring: the mediating effects of obstetric and neonatal complications.BMC medicine · 2023Article
- Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania.Children (Basel, Switzerland) · 2023Article
- Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries.BMJ open · 2023Article
- The Influence of Parent Education on the Neurobehavior and Sucking Reflexes of Very Preterm Infants.Brain sciences · 2022Article
- Priority setting in early childhood development: an analytical framework for economic evaluation of interventions.BMJ global health · 2022Article
- Early detection and intervention for young children with early developmental disabilities in Western Uganda: a mixed-methods evaluation.BMC pediatrics · 2022Article
- Early care and support for young children with developmental disabilities and their caregivers in Uganda: The Baby Ubuntu feasibility trial.Frontiers in pediatrics · 2022Article
- Measuring early child development across low and middle-income countries: A systematic review.Journal of early childhood research : ECR · 2021Article
- Need for more evidence in the prevention and management of perinatal asphyxia and neonatal encephalopathy in low and middle-income countries: A call for action.Seminars in fetal & neonatal medicine · 2021Review
- Article
- Is integrated private-clinic based early child development care effective? A clustered randomised trial in Pakistan.BJGP open · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
Abstract
objectiveTo determine if early developmental intervention (EDI) improves developmental abilities in resuscitated children. STUDY
designThis was a parallel group, randomized controlled trial of infants unresponsive to stimulation who received bag and mask ventilation as part of their resuscitation at birth and infants who did not require any resuscitation born in rural communities in India, Pakistan, and Zambia. Intervention infants received a parent-implemented EDI delivered with home visits by parent trainers every other week for 3 years starting the first month after birth. Parents in both intervention and control groups received health and safety counseling during home visits on the same schedule. The main outcome measure was the Mental Development Index (MDI) of the Bayley Scales of Infant Development, 2nd edition, assessed at 36 months by evaluators unaware of treatment group and resuscitation history.
resultsMDI was higher in the EDI (102.6 ± 9.8) compared with the control resuscitated children (98.0 ± 14.6, 1-sided P = .0202), but there was no difference between groups in the nonresuscitated children (100.1 ± 10.7 vs 97.7 ± 10.4, P = .1392). The Psychomotor Development Index was higher in the EDI group for both the resuscitated (P = .0430) and nonresuscitated children (P = .0164).
conclusionsThis trial of home-based, parent provided EDI in children resuscitated at birth provides evidence of treatment benefits on cognitive and psychomotor outcomes. MDI and Psychomotor Development Index scores of both nonresuscitated and resuscitated infants were within normal range, independent of early intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.