ArticleComparative hepatology2012
The genetic regulation of the terminating phase of liver regeneration.
Article in Comparative hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Article
- Surgical Models of Liver Regeneration in Pigs: A Practical Review of the Literature for Researchers.Cells · 2023Review
- F4/80Molecules (Basel, Switzerland) · 2021Article
- Unaltered Liver Regeneration in Post-Cholestatic Rats Treated with the FXR Agonist Obeticholic Acid.Biomolecules · 2021Article
- Liver Regeneration: Analysis of the Main Relevant Signaling Molecules.Mediators of inflammation · 2017Review
- Systems Analysis of the Complement-Induced Priming Phase of Liver Regeneration.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- MicroRNAs in the Evaluation and Potential Treatment of Liver Diseases.Journal of clinical medicine · 2016Review
- Transcriptomic characterization of the dorsal lobes after hepatectomy of the ventral lobe in zebrafish.BMC genomics · 2015Article
- p300 Regulates Liver Functions by Controlling p53 and C/EBP Family Proteins through Multiple Signaling Pathways.Molecular and cellular biology · 2015Article
- In vitro culture of isolated primary hepatocytes and stem cell-derived hepatocyte-like cells for liver regeneration.Protein & cell · 2015Review
- Tissue Remodelling following Resection of Porcine Liver.BioMed research international · 2015Article
- Cooperation of C/EBP family proteins and chromatin remodeling proteins is essential for termination of liver regeneration.Hepatology (Baltimore, Md.) · 2015Article
- To divide or not to divide: revisiting liver regeneration.Cell division · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundAfter partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating phase of liver regeneration, we performed a 60% PHx in a porcine model. Liver biopsies were taken at the time of resection, after three weeks and upon termination the sixth week. Gene expression profiles were obtained using porcine oligonucleotide microarrays. Our study reveals the interactions between genes regulating the cell cycle, apoptosis and angiogenesis, and the role of Transforming Growth Factor-β (TGF-β) signalling towards the end of liver regeneration.
resultsMicroarray analysis revealed a dominance of genes regulating apoptosis towards the end of regeneration. Caspase Recruitment Domain-Containing Protein 11 (CARD11) was up-regulated six weeks after PHx, suggesting the involvement of the caspase system at this time. Zinc Finger Protein (ZNF490) gene, with a potential negative effect on cell cycle progression, was only up-regulated at three and six weeks after PHx indicating a central role at this time. TGF-β regulation was not found to be significantly affected in the terminating phase of liver regeneration. Vasohibin 2 (VASH2) was down-regulated towards the end of regeneration, and may indicate a role in preventing a continued vascularization process.
conclusionsCARD11, ZNF490 and VASH2 are differentially expressed in the termination phase of liver regeneration. The lack of TGF-β up-regulation suggests that signalling by TGF-β is not required for termination of liver regeneration.
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Registered trials
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