Evidence map›Paper›PMID 23164177›Full record

ReviewClinics in perinatology2012

Physiology of transition from intrauterine to extrauterine life.

Noah H Hillman, Suhas G Kallapur, Alan H Jobe

Registry-linked trialAbstract readReview
In one paragraph

Review in Clinics in perinatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07773896 (The Effect of Infant Massage Applied at Different Durations on Comfort and Physiological Stability in Late Preterm Infants Receiving nCPAP), which is not on this map. Cited by 170 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07773896 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Effect of Infant Massage Applied at Different Durations on Comfort and Physiological Stability in Late Preterm Infants Receiving nCPAP

TypeinterventionalSponsorTarsus UniversityRan2026 to 2027Enrolled90ConditionsNeonatal, PretermArms1. İntervention group, 2. İntervention group
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. Embracing non-linearity in human ageing.Nature reviews. Genetics · 2026
    Review
  13. Observational
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  15. Observational
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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noah H HillmanDivision of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, 3333 Burnet Avenue, ML#7029, Cincinnati, OH 45229-3039, USA.
Suhas G Kallapur
Alan H Jobe

Funding

Initiation and Progression of Preterm Lung Injury with VentilationR01HD072842 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI JOBE, ALAN H · 2012 to 2016
$1.4M
Lung Injury with Resuscitation of the PretermK08HL097085 · NHLBI · SAINT LOUIS UNIVERSITY · PI HILLMAN, NOAH H · 2009 to 2013
$644k
NHLBI NIH HHS K08 HL097085NHLBI NIH HHS K08-HL097085NICHD NIH HHS R01 HD072842NICHD NIH HHS R01-HD072842
6 · The paper itself

Abstract

The transition from fetus to newborn is the most complex adaptation that occurs in human experience. Lung adaptation requires coordinated clearance of fetal lung fluid, surfactant secretion, and onset of consistent breathing. The cardiovascular response requires striking changes in blood flow, pressures, and pulmonary vasodilation. Energy metabolism and thermoregulation must be quickly controlled. The primary mediators that prepare the fetus for birth and support the multiorgan transition are cortisol and catecholamine. Abnormalities in adaptation are frequently found following preterm birth or cesarean delivery at term, and many of these infants need delivery room resuscitation to assist in this transition.

Indexed as

Adaptation, PhysiologicalCardiovascular Physiological PhenomenaBody Temperature RegulationCatecholaminesDelivery, ObstetricEnergy MetabolismFemaleFetusHumansHydrocortisoneInfant, NewbornLungPregnancyThyroid HormonesCatecholaminesHydrocortisoneThyroid Hormones

Identifiers

PMID23164177
PMCPMC3504352

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.