Evidence map›Paper›PMID 23164083›Full record

ReviewRegenerative medicine2012

Stem cell recruitment after injury: lessons for regenerative medicine.

Robert C Rennert, Michael Sorkin, Ravi K Garg, Geoffrey C Gurtner

Abstract readReview
In one paragraph

Review in Regenerative medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Deciphering the aging process through single-cell cytometric technologies.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Stem Cell Therapy: From Idea to Clinical Practice.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Robert C RennertHagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic & Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, 257 Campus Drive West, Hagey Building GK-201, Stanford, CA 94305-5148, USA.
Michael Sorkin
Ravi K Garg
Geoffrey C Gurtner

Funding

Reversal of Progenitor Cell Deficits in DiabetesR01DK074095 · NIDDK · UNIVERSITY OF ARIZONA · PI GURTNER, GEOFFREY C · 2005 to 2025
$6.4M
Targeting HIF-1 alpha Dysfunction in Complications of AgingR01AG025016 · NIA · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C · 2004 to 2015
$3.5M
Inside-Out Tissue Engineering for Organ FabricationR01EB005718 · NIBIB · STANFORD UNIVERSITY · PI GURTNER, GEOFFREY C, LONGAKER, MICHAEL T · 2010 to 2013
$1.4M
Progenitor Cell Dysfunction and Impaired Neovascularization in DiabetesR56DK074095 · NIDDK · STANFORD UNIVERSITY · PI BROWNLEE, MICHAEL A, GURTNER, GEOFFREY C · 2009 to 2009
$500k
NIA NIH HHS 2 RO1 AG025016NIA NIH HHS R01 AG025016NIBIB NIH HHS 5 R01 EB005718-02NIBIB NIH HHS R01 EB005718NIDDK NIH HHS 2 RO1 DK074095-07NIDDK NIH HHS R01 DK074095NIDDK NIH HHS R56 DK074095
6 · The paper itself

Abstract

Tissue repair and regeneration are thought to involve resident cell proliferation as well as the selective recruitment of circulating stem and progenitor cell populations through complex signaling cascades. Many of these recruited cells originate from the bone marrow, and specific subpopulations of bone marrow cells have been isolated and used to augment adult tissue regeneration in preclinical models. Clinical studies of cell-based therapies have reported mixed results, however, and a variety of approaches to enhance the regenerative capacity of stem cell therapies are being developed based on emerging insights into the mechanisms of progenitor cell biology and recruitment following injury. This article discusses the function and mechanisms of recruitment of important bone marrow-derived stem and progenitor cell populations following injury, as well as the emerging therapeutic applications targeting these cells.

Indexed as

Bone Marrow CellsBone Marrow TransplantationRegenerationAdult Stem CellsAnimalsHumansRegenerative MedicineWounds and Injuries

Identifiers

PMID23164083
PMCPMC3568672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.