ArticleBMC infectious diseases2012
An expanded age range for meningococcal meningitis: molecular diagnostic evidence from population-based surveillance in Asia.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Global epidemiology of serogroup Y invasive meningococcal disease: a literature review.Epidemiology and infection · 2024Pooled it
- Multiple Cross Displacement Amplification Combined with Real-Time Fluorescence Monitoring for Efficient, Specific, and SensitiveACS omega · 2024Article
- 4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion.Infectious diseases and therapy · 2024Article
- CharacterizingIJID regions · 2024Article
- Review of the epidemiology, diagnosis and management of invasive meningococcal disease in Vietnam.Human vaccines & immunotherapeutics · 2023Review
- Pathogenomic in silico approach identifies NSP-A and Fe-IIISBP as possible drug targets in Neisseria Meningitidis MC58 and development of pharmacophores as novel therapeutic candidates.Molecular diversity · 2023Article
- Invasive meningococcal disease in Malaysia, Philippines, Thailand, and Vietnam: An Asia-Pacific expert group perspective on current epidemiology and vaccination policies.Human vaccines & immunotherapeutics · 2022Article
- Post-Marketing Surveillance Observational Study of Quadrivalent Meningococcal Diphtheria Toxoid Conjugate Vaccine (MenACWY-DT, MCV4/MenactraInfectious diseases and therapy · 2021Article
- Molecular characteristics of Neisseria meningitidis in Qatar.Scientific reports · 2021Article
- One-year antibody persistence and safety of a 4-dose schedule of MenACWY-CRM in healthy infants from South Korea.Clinical and experimental vaccine research · 2019Article
- Development of a multiple cross displacement amplification combined with nanoparticles-based biosensor assay to detectInfection and drug resistance · 2019Article
- Prevalence and serogroup changes of Neisseria meningitidis in South Korea, 2010-2016.Scientific reports · 2018Article
- Effects of meteorological factors on the incidence ofAfrican health sciences · 2017Article
- Immunogenicity of MenACWY-CRM in Korean Military Recruits: Influence of Tetanus-Diphtheria Toxoid Vaccination on the Vaccine Response to MenACWY-CRM.Yonsei medical journal · 2016Article
- Meningococcal Disease in Korea: an Epidemiologic Study of the Underestimated Infectious Disease.Infection & chemotherapy · 2016Article
- A Survey of Serum Bactericidal Antibodies against Neisseria meningitidis Serogroups A, C, W and Y in Adolescents and Adults in the Republic of Korea.Infection & chemotherapy · 2016Article
- Cluster of serogroup W-135 meningococcal disease in 3 military recruits.Journal of Korean medical science · 2015Article
- Revised adult immunization guideline recommended by the korean society of infectious diseases, 2014.Infection & chemotherapy · 2015Review
- A Novel Loop-Mediated Isothermal Amplification Assay for Serogroup Identification of Neisseria meningitidis in Cerebrospinal Fluid.Frontiers in microbiology · 2015Article
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Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo understand epidemiologic patterns of meningococcal disease in Asia, we performed a retrospective molecular analysis of cerebrospinal fluid (CSF) specimens collected in prospective surveillance among children aged < 5 years of age in China, South Korea, and Vietnam.
methodsA total of 295 isolates and 2,302 CSFs were tested by a meningococcal species- and serogroup-specific polymerase chain reaction (PCR) assay targeting the Neisseria meningitidis (Nm) ctrA gene. Multi-locus sequence typing (MLST) was performed in Nm gene amplification analysis and incidence rates for meningococcal meningitis were estimated.
resultsAmong 295 isolates tested, 10 specimens from Vietnam were confirmed as serogroup B and all were Sequence Type (ST) 1576 by MLST. Among the 2,032 CSF specimen tested, 284 (14%) were confirmed by PCR (ctrA gene), including 67 (23.6%) from China, 92 (32.4%) from Korea, and 125 (44.0%) from Vietnam. Neonates and infants aged < 6 months of age accounted for more than 50% of Nm-PCR positive CSF. Two CSF specimens from Vietnam were identified as serogroup B using MLST. In addition, 44 specimens underwent sequencing to confirm meningococcal serogroup; of these, 21 (48%) were serogroup C, 12 (27%) were serogroup X, 9 (20%) were serogroup Y and 2 (5%) were serogroup B. The incidence rates of meningococcal meningitis among children < 5 years of age was highest in Vietnam (7.4/100,000 [95% CI, 3.6-15.3] followed by Korea (6.8/100,000 [95% CI, 3.5-13.5] and China (2.1/100,000) [95% CI, 0.7-6.2]).
conclusionsThese results suggest that there is a previously undetected, yet substantial burden of meningococcal meningitis among infants and young children. Standardized, sensitive and specific molecular diagnostic assays with Nm serogrouping capacity are needed throughout Asia to understand the true burden of N. meningitidis disease.
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