ArticleVirology journal2012
Diagnostic value of respiratory virus detection in symptomatic children using real-time PCR.
Article in Virology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic value of BinaxNOW antigen card for Severe Acute Respiratory Syndrome Coronavirus 2.Bioengineered · 2023Pooled it
- Evaluation of a fully automatic nucleic acid amplification system for detecting four respiratory pathogens.Pediatric research · 2025Article
- Article
- Epidemiological characteristics of adenovirus in children in Yancheng, China, 2023-2024.Frontiers in cellular and infection microbiology · 2025Article
- Article
- Observational Study on the Clinical Reality of Community-Acquired Respiratory Virus Infections in Adults and Older Individuals.Pathogens (Basel, Switzerland) · 2024Observational
- Respiratory virus infections in symptomatic and asymptomatic children upon hospital admission: new insights.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Prevalence of Influenza Viruses A and B, Adenovirus, Respiratory Syncytial Virus, and Human Metapneumonia Viruses among Children with Acute Respiratory Tract Infection.Advances in virology · 2024Article
- High incidence of the virus among respiratory pathogens in children with lower respiratory tract infection in northwestern China.Journal of medical virology · 2023Article
- Association of children wheezing diseases with meteorological and environmental factors in Suzhou, China.Scientific reports · 2022Article
- Evaluation of viral respiratory pathogens in children aged under five hospitalized with lower respiratory tract infections.Northern clinics of Istanbul · 2022Article
- Conventional and microfluidic methods for airborne virus isolation and detection.Colloids and surfaces. B, Biointerfaces · 2021Review
- Potential Diagnostic and Prognostic Biomarkers for Adenovirus Respiratory Infection in Children and Young Adults.Viruses · 2021Review
- Circulation profile of respiratory viruses in symptomatic and asymptomatic children from Midwest Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Respiratory Virus Co-infection in Acute Respiratory Infections in Children.Current infectious disease reports · 2020Review
- Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR.International journal of environmental research and public health · 2020Article
- Influence of viral load in the outcome of hospitalized patients with influenza virus infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Observational
- Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018Article
- Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection.Cell reports · 2018Article
- Etiology of Coinfections in Children with Influenza during 2015/16 Winter Season in Nepal.International journal of microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory tract infections are an important public health problem. Sensitive and rapid diagnostic techniques have been developed and are used in daily clinical practice. Here we evaluate the clinical relevance of detecting 20 common respiratory pathogens by molecular methods in a general pediatric clinic.
methodsNasopharynx samples of children < 18 years of age with respiratory symptoms referred to a general pediatric clinic were tested for the presence of 19 viruses and Mycoplasma pneumoniae, using real-time polymerase chain reaction.
resultsOf 177 patients included in this retrospective study, 73% were positive for at least one virus. Respiratory syncytial virus (36.6%) and human rhinovirus (24%) were most frequently detected. Patients in whom a respiratory virus or Mycoplasma pneumoniae was detected, were younger (6 versus 24 months; p < 0.001) and more often hospitalized (116 versus 34; p = 0.001) than patients in whom no respiratory pathogen was detected. Also they were more likely to present with feeding problems, dyspnea, rhinorrhea and wheezing (all p < 0.05) than patients without a respiratory pathogen.In the majority of cases, clinicians did not change their antibiotic management after detecting a viral respiratory pathogen. No difference in mean Ct value was found between patients with one respiratory pathogen and those with >1 respiratory pathogen (30.5 versus 31.2; p = 0.573).
conclusionRoutine testing of common respiratory pathogens could lead to a better understanding of their role in disease in children with respiratory symptoms.
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