ArticleNutrition and cancer2012
Effects of Tepary bean (Phaseolus acutifolius) protease inhibitor and semipure lectin fractions on cancer cells.
Article in Nutrition and cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Purification, Characterization and Bioactivity of a New Homodimeric Lectin FromPlant-environment interactions (Hoboken, N.J.) · 2025Article
- Article
- Tepary Bean (International journal of molecular sciences · 2025Article
- Advances in the application and mechanism of bioactive peptides in the treatment of inflammation.Frontiers in immunology · 2024Review
- EGFR and p38Pharmaceuticals (Basel, Switzerland) · 2023Article
- Comparative study, homology modelling and molecular docking with cancer associated glycans of two non-fetuin-binding Tepary bean lectins.Glycoconjugate journal · 2023Article
- Effect of Induced Mechanical Leaf Damage on the Yield and Content of Bioactive Molecules in Leaves and Seeds of Tepary Beans (Plants (Basel, Switzerland) · 2022Article
- Potential Role of Bioactive Proteins and Peptides Derived from Legumes towards Metabolic Syndrome.Nutrients · 2022Review
- Bioaccessibility andInternational journal of molecular sciences · 2021Article
- Protein Concentrates on Tepary Bean (Frontiers in nutrition · 2021Article
- Tepary bean (Toxicology research · 2020Article
- Recombinant Lectin from Tepary Bean (Biomolecules · 2020Article
- Quantum Dot Labelling of Tepary Bean (Molecules (Basel, Switzerland) · 2020Article
- Tepary Bean (Molecules (Basel, Switzerland) · 2020Article
- Effects of intragastrically-administered Tepary bean lectins on digestive and immune organs: Preclinical evaluation.Toxicology reports · 2018Article
- Phaseolus acutifolius Lectin Fractions Exhibit Apoptotic Effects on Colon Cancer: Preclinical Studies Using Dimethilhydrazine or Azoxi-Methane as Cancer Induction Agents.Molecules (Basel, Switzerland) · 2017Article
- Plant Lectins as Medical Tools against Digestive System Cancers.International journal of molecular sciences · 2017Review
- Plant Protease Inhibitors in Therapeutics-Focus on Cancer Therapy.Frontiers in pharmacology · 2016Review
- Tolerability assessment of a lectin fraction from Tepary bean seeds (Toxicology reports · 2015Article
- Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects.International journal of molecular sciences · 2014Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Some natural and synthetic protease inhibitors (PI), such as the Bowman-Birk PI from soybean, have anticancer effects. We previously purified and characterized a Bowman-Birk-type PI from Tepary bean (Phaseolus acutifolius) seeds (TBPI). A semipure protein fraction containing this inhibitor, when tested its in vitro effect on transformed cells, showed a differential cytotoxic effect, as well as an increase in cell attachment to culture dishes. In this article we report that lectins were responsible for the cytotoxic effect previously observed, exhibiting a differential, antiproliferative effect on nontransformed cells and on different lineages of cancer cells. Although the purified TBPI lacked cytotoxicity, it was found to be responsible for the increase in cell adhesion, decreasing culture dishes' extracellular matrix degradation, leading to a decrease of the in vitro cell invasion capacity. This effect coincided with the suppression of Matrix Metalloproteinase-9 activity. These results indicate that Tepary bean seeds contain at least 2 different groups of bioactive proteins with distinct effects on cancer cells.
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