ArticleExperimental dermatology2012
Lack of microRNA miR-150 reduces the capacity of epidermal Langerhans cell cross-presentation.
Article in Experimental dermatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Reduced atherosclerosis lesion size, inflammatory response in miR-150 knockout mice via macrophage effects.Journal of lipid research · 2018Article
- miR-181a and miR-150 regulate dendritic cell immune inflammatory responses and cardiomyocyte apoptosis via targeting JAK1-STAT1/c-Fos pathway.Journal of cellular and molecular medicine · 2017Article
- Endogenous and tumour-derived microRNAs regulate cross-presentation in dendritic cells and consequently cytotoxic T cell function.Cytotechnology · 2016Review
- Article
- MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway.Immunology letters · 2016Article
- miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation.World journal of gastroenterology · 2016Review
- Osteoporotic bone of miR-150-deficient mice: Possibly due to low serum OPG-mediated osteoclast activation.Bone reports · 2015Article
- microRNAs function in CD8+T cell biology.Journal of leukocyte biology · 2015Review
- MicroRNAs affect dendritic cell function and phenotype.Immunology · 2015Review
- The role of microRNAs in lymphopoiesis.International journal of hematology · 2014Review
- Small and Long Regulatory RNAs in the Immune System and Immune Diseases.Frontiers in immunology · 2014Review
- microRNA miR-17-92 cluster is highly expressed in epidermal Langerhans cells but not required for its development.Genes and immunity · 2014Article
- Dendritic Cell Plasticity in Tumor-Conditioned Skin: CD14(+) Cells at the Cross-Roads of Immune Activation and Suppression.Frontiers in immunology · 2013Review
- Deletion of microRNA miR-223 increases Langerhans cell cross-presentation.The international journal of biochemistry & cell biology · 2013Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that repress target genes at post-transcriptional level. Langerhans cells (LCs) are skin-residential dendritic cells (DCs) with a life cycle distinct from other types of DCs. miRNA deficiency interrupts the homoeostasis and function of epidermal LCs, suggesting the critical roles of miRNAs in LC development and function. However, the roles of individual miRNAs in regulating LC development and function remain completely unknown. MiRNA miR-150 is highly expressed in mature lymphocytes and regulates T- and B-cell development and function. Here, we reported that miR-150 is also expressed in epidermal LCs, and its expression is significantly down-regulated during in vitro LC maturation. Using a miR-150 knockout mouse model, we found that lack of miR-150 reduces the capacity of LCs to cross-present a soluble antigen to antigen-specific CD8(+) T cells, but does not disturb the development, maturation, migration and phagocytic capacity of LCs. Thus, our data indicate that miR-150 is required for LC cross-presentation.
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Registered trials
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