ArticleBiomedical optics express2012
In vivo photothermal optical coherence tomography of gold nanorod contrast agents.
Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Phase-sensitive photothermal optical coherence tomography: decoupling optical and thermal tissue properties.Biomedical optics express · 2026Article
- Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.Scientific reports · 2024Article
- Photothermal optical coherence tomography for 3D live cell detection and mapping.Optics continuum · 2023Article
- Review
- Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens.Scientific reports · 2023Article
- Three-dimensional opto-thermo-mechanical model for predicting photo-thermal optical coherence tomography responses in multilayer geometries.Biomedical optics express · 2022Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Spectroscopic thermo-elastic optical coherence tomography for tissue characterization.Biomedical optics express · 2022Article
- Optical coherence tomography.Nature reviews. Methods primers · 2022Article
- Gold nanomaterials for optical biosensing and bioimaging.Nanoscale advances · 2021Review
- Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods as Contrast Agents.Translational vision science & technology · 2019Article
- Potentials and pitfalls of gold-silica nanoshell as the exogenous contrast agent for optical diagnosis of cancers: a numerical parametric study.Lasers in medical science · 2019Article
- Photothermal optical coherence tomography of indocyanine green in ex vivo eyes.Optics letters · 2018Article
- Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography.Translational vision science & technology · 2018Article
- In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.Scientific reports · 2017Article
- Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2017Review
- Using Multifunctional Peptide Conjugated Au Nanorods for Monitoring β-amyloid Aggregation and Chemo-Photothermal Treatment of Alzheimer's Disease.Theranostics · 2017Article
- Depth-resolved analytical model and correction algorithm for photothermal optical coherence tomography.Biomedical optics express · 2016Article
- Fast 3D visualization of endogenous brain signals with high-sensitivity laser scanning photothermal microscopy.Biomedical optics express · 2016Article
- Dispersion-based stimulated Raman scattering spectroscopy, holography, and optical coherence tomography.Optics express · 2016Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Photothermal optical coherence tomography (PT-OCT) is a potentially powerful tool for molecular imaging. Here, we characterize PT-OCT imaging of gold nanorod (GNR) contrast agents in phantoms, and we apply these techniques for in vivo GNR imaging. The PT-OCT signal was compared to the bio-heat equation in phantoms, and in vivo PT-OCT images were acquired from subcutaneous 400 pM GNR Matrigel injections into mice. Experiments revealed that PT-OCT signals varied as predicted by the bio-heat equation, with significant PT-OCT signal increases at 7.5 pM GNR compared to a scattering control (p < 0.01) while imaging in common path configuration. In vivo PT-OCT images demonstrated an appreciable increase in signal in the presence of GNRs compared to controls. Additionally, in vivo PT-OCT GNR signals were spatially distinct from blood vessels imaged with Doppler OCT. We anticipate that the demonstrated in vivo PT-OCT sensitivity to GNR contrast agents is sufficient to image molecular expression in vivo. Therefore, this work demonstrates the translation of PT-OCT to in vivo imaging and represents the next step towards its use as an in vivo molecular imaging tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.