ArticleBiomedical optics express2012
Tissue dynamics spectroscopy for phenotypic profiling of drug effects in three-dimensional culture.
Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Dynamic speckle, reduced extinction, and multiple scattering in holographic optical coherence imaging.Biomedical optics express · 2026Article
- Compressed intracellular motility via non-uniform temporal sampling in dynamic optical coherence tomography.Journal of biomedical optics · 2024Article
- Comparative oncology chemosensitivity assay for personalized medicine using low-coherence digital holography of dynamic light scattering from cancer biopsies.Scientific reports · 2024Article
- Evaluating the feasibility and predictive accuracy of biodynamic imaging to platinum-based chemotherapy response in esophageal adenocarcinoma.Frontiers in oncology · 2024Article
- Biodynamic signatures from ex vivo bone marrow aspirates are associated with chemotherapy-induced neutropenia in cancer-bearing dogs.Veterinary medicine and science · 2021Article
- Doppler imaging detects bacterial infection of living tissue.Communications biology · 2021Article
- Biodynamic digital holographic speckle microscopy for oocyte and embryo metabolic evaluation.Applied optics · 2021Article
- Optical coherence tomography-based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroids.Biomedical optics express · 2020Article
- Intracellular optical doppler phenotypes of chemosensitivity in human epithelial ovarian cancer.Scientific reports · 2020Article
- Tissue dynamics spectroscopic imaging: functional imaging of heterogeneous cancer tissue.Journal of biomedical optics · 2020Article
- Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility.Quantitative imaging in medicine and surgery · 2020Article
- Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein.Biochemical and biophysical research communications · 2019Article
- Doppler fluctuation spectroscopy of intracellular dynamics in living tissue.Journal of the Optical Society of America. A, Optics, image science, and vision · 2019Article
- Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma.Biomedical optics express · 2018Article
- Quantification of the Effect of Toxicants on the Intracellular Kinetic Energy and Cross-Sectional Area of Mammary Epithelial Organoids by OCT Fluctuation Spectroscopy.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Review
- Biodynamic imaging for phenotypic profiling of three-dimensional tissue culture.Journal of biomedical optics · 2017Article
- Intracellular dynamics measurements with full field optical coherence tomography suggest hindering effect of actomyosin contractility on organelle transport.Biomedical optics express · 2016Article
- Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts.Scientific reports · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coherence-gated dynamic light scattering captures cellular dynamics through ultra-low-frequency (0.005-5 Hz) speckle fluctuations and Doppler shifts that encode a broad range of cellular and subcellular motions. The dynamic physiological response of tissues to applied drugs is the basis for a new type of phenotypic profiling for drug screening on multicellular tumor spheroids. Volumetrically resolved tissue-response fluctuation spectrograms act as fingerprints that are segmented through feature masks into high-dimensional feature vectors. Drug-response clustering is achieved through multidimensional scaling with simulated annealing to construct phenotypic drug profiles that cluster drugs with similar responses. Hypoxic vs. normoxic tissue responses present two distinct phenotypes with differentiated responses to environmental perturbations and to pharmacological doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.