ArticleFrontiers in genetics2012
Using blood informative transcripts in geographical genomics: impact of lifestyle on gene expression in fijians.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
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- Molecular approaches to the diagnosis and monitoring of production diseases in pigs.Research in veterinary science · 2017Review
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- Signature of positive selection of PTK6 gene in East Asian populations: a cross talk for Helicobacter pylori invasion and gastric cancer endemicity.Molecular genetics and genomics : MGG · 2015Article
- Omic personality: implications of stable transcript and methylation profiles for personalized medicine.Genome medicine · 2015Article
- Mesenchymal Stromal Cells Derived From Crohn's Patients Deploy Indoleamine 2,3-dioxygenase-mediated Immune Suppression, Independent of Autophagy.Molecular therapy : the journal of the American Society of Gene Therapy · 2015Article
- Combined genetic effects of EGLN1 and VWF modulate thrombotic outcome in hypoxia revealed by Ayurgenomics approach.Journal of translational medicine · 2015Article
- Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- The transition from a rural to an urban environment alters expression of the human Ebola virus receptor Neiman-Pick C1: implications for the current epidemic in West Africa.Cell stress & chaperones · 2015Article
- Blood gene expression profiles suggest altered immune function associated with symptoms of generalized anxiety disorder.Brain, behavior, and immunity · 2015Article
- Expression quantitative trait locus analysis for translational medicine.Genome medicine · 2015Review
- Human social genomics.PLoS genetics · 2014Review
- Mapping eQTLs in the Norfolk Island genetic isolate identifies candidate genes for CVD risk traits.American journal of human genetics · 2013Article
- Geographical, environmental and pathophysiological influences on the human blood transcriptome.Current genetic medicine reports · 2013Article
- Genetic and nongenetic variation revealed for the principal components of human gene expression.Genetics · 2013Article
- Analysis of the transcriptome in molecular epidemiology studies.Environmental and molecular mutagenesis · 2013Review
- Blood-informative transcripts define nine common axes of peripheral blood gene expression.PLoS genetics · 2013Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
In previous geographical genomics studies of the impact of lifestyle on gene expression inferred from microarray analysis of peripheral blood samples, we described the complex influences of culture, ethnicity, and gender in Morocco, and of pregnancy in Brisbane. Here we describe the use of nanofluidic Fluidigm quantitative RT-PCR arrays targeted at a set of 96 transcripts that are broadly informative of the major axes of immune gene expression, to explore the population structure of transcription in Fiji. As in Morocco, major differences are seen between the peripheral blood transcriptomes of rural villagers and residents of the capital city, Suva. The effect is much greater in Indian villages than in Melanesian highlanders and appears to be similar with respect to the nature of at least two axes of variation. Gender differences are much smaller than ethnicity or lifestyle effects. Body mass index is shown to associate with one of the axes as it does in Atlanta and Brisbane, establishing a link between the epidemiological transition of human metabolic disease, and gene expression profiles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.