ArticleFrontiers in plant science2012
Plant mitochondrial retrograde signaling: post-translational modifications enter the stage.
Article in Frontiers in plant science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Metabolite-driven protein modifications in immune signaling: from established principles to emerging pyruvylation.Frontiers in immunology · 2026Review
- Unraveling the Role of AtSRT2 in Energy Metabolism, Stress Responses, and Gene Expression during Osmotic Stress inPlants (Basel, Switzerland) · 2024Article
- Fine Tuning of ROS, Redox and Energy Regulatory Systems Associated with the Functions of Chloroplasts and Mitochondria in Plants under Heat Stress.International journal of molecular sciences · 2023Review
- Retrograde signaling in plants: A critical review focusing on the GUN pathway and beyond.Plant communications · 2023Review
- Advances in proteome-wide analysis of plant lysine acetylation.Plant communications · 2022Review
- Extensive Posttranscriptional Regulation of Nuclear Gene Expression by Plastid Retrograde Signals.Plant physiology · 2019Article
- Considerations of AOX Functionality Revealed by Critical Motifs and Unique Domains.International journal of molecular sciences · 2018Article
- Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants.Plant physiology · 2018Review
- Genome-wide identification and analysis of the ALTERNATIVE OXIDASE gene family in diploid and hexaploid wheat.PloS one · 2018Article
- Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins inMolecular systems biology · 2017Article
- Glutathionylation of Pea Chloroplast 2-Cys Prx and Mitochondrial Prx IIF Affects Their Structure and Peroxidase Activity and Sulfiredoxin Deglutathionylates Only the 2-Cys Prx.Frontiers in plant science · 2017Article
- The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism.Plant physiology · 2014Article
- In silico analysis of protein Lys-N(𝜀)-acetylation in plants.Frontiers in plant science · 2014Review
- Mitochondrial energy and redox signaling in plants.Antioxidants & redox signaling · 2013Review
- Dissecting the integrative antioxidant and redox systems in plant mitochondria. Effect of stress and S-nitrosylation.Frontiers in plant science · 2013Article
- Retrograde signals galore.Frontiers in plant science · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beside their central function in respiration plant mitochondria play important roles in diverse processes such as redox homeostasis, provision of precursor molecules for essential biosynthetic pathways, and programmed cell death. These different functions require the organelle to communicate with the rest of the cell by perceiving, transducing, and emitting signals. As the vast majority of mitochondrial proteins are encoded in the nuclear genome, changes in mitochondrial status must be fed back to the nucleus to coordinate gene expression accordingly, a process termed retrograde signaling. However, the nature of these signaling pathways in plants and their underlying signaling molecules - or indirect metabolite or redox signals - are not completely resolved. We explore the potential of different post-translational modifications (PTMs) to contribute to mitochondrial retrograde signaling. Remarkably, the substrates used for modifying proteins in many major PTMs are either central metabolites or redox-active compounds, as for example ATP, acetyl-CoA, NAD(+), and glutathione. This suggests that the metabolic status of organelles and of the cell in general could be indirectly gaged by the enzymes catalyzing the various PTMs. We examine the evidence supporting this hypothesis with regard to three major PTMs, namely phosphorylation, lysine acetylation, and glutathionylation and assess their potential to regulate not only organellar processes by modifying metabolic enzymes but also to influence nuclear gene expression.
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