ArticleFrontiers in integrative neuroscience2012
The detrimental effects of emotional process dysregulation on decision-making in substance dependence.
Article in Frontiers in integrative neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Emotion regulation in substance use disorders: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2023Pooled it
- Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review.Psychopharmacology · 2020Pooled it
- Clinical Correlates of Compliance, Appeasement and Resistance in Command Hallucinations: A Systematic Review.Clinical psychology & psychotherapyPooled it
- Automated Facial Emotion Recognition System Detects Altered Emotional Processing During Craving Induction in Individuals with Substance Use Disorder.Healthcare (Basel, Switzerland) · 2026Article
- Within-person affect dynamics among individuals in residential treatment for opioid use disorder: An ecological momentary assessment study.Journal of psychopathology and clinical science · 2025Article
- The therapeutic potential of low-intensity focused ultrasound for treating substance use disorder.Frontiers in psychiatry · 2024Review
- Wellbeing in Addiction Recovery: Does It Differ across Addictions?International journal of environmental research and public health · 2023Article
- Is Illicit Substance Use Gender-Specific? The Basic Points of Mental and Health Disorders.Toxics · 2022Review
- Selective D3 receptor antagonism modulates neural response during negative emotional processing in substance dependence.Frontiers in psychiatry · 2022Article
- Understanding the Progression from Early Alcohol Use Experimentation to Alcohol Use Disorder: Testing Vulnerability by Experience Interactions Using a Two-Part Latent Growth Curve Model.Research on child and adolescent psychopathology · 2021Article
- Treatment Efficacy of Internet Gaming Disorder With Attention Deficit Hyperactivity Disorder and Emotional Dysregulaton.The international journal of neuropsychopharmacology · 2020Article
- Visual Ethnography: Decriminalization and Stable Housing Equals Motivation, Stability, and Recovery Among Latinx Populations.American journal of public health · 2020Article
- Trajectories of marijuana use from late childhood to late adolescence: Can Temperament × Experience interactions discriminate different trajectories of marijuana use?Development and psychopathology · 2017Article
- Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum.Neuroscience · 2014Article
- Current research and emerging directions in emotion-cognition interactions.Frontiers in integrative neuroscience · 2014Article
- Psychopathological symptoms of patients with heroin addiction entering opioid agonist or therapeutic community treatment.Annals of general psychiatry · 2014Article
- Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults.PloS one · 2014Article
- Correlation of cognitive functions with emotional dysregulation in alcohol dependence: A preliminary study.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Substance dependence is complex and multifactorial, with many distinct pathways involved in both the development and subsequent maintenance of addictive behaviors. Various cognitive mechanisms have been implicated, including impulsivity, compulsivity, and impaired decision-making. These mechanisms are modulated by emotional processes, resulting in increased likelihood of initial drug use, sustained substance dependence, and increased relapse during periods of abstinence. Emotional traits, such as sensation-seeking, are risk factors for substance use, and chronic drug use can result in further emotional dysregulation via effects on reward, motivation, and stress systems. We will explore theories of hyper and hypo sensitivity of the brain reward systems that may underpin motivational abnormalities and anhedonia. Disturbances in these systems contribute to the biasing of emotional processing toward cues related to drug use at the expense of natural rewards, which serves to maintain addictive behavior, via enhanced drug craving. We will additionally focus on the sensitization of the brain stress systems that result in negative affect states that continue into protracted abstinence that is may lead to compulsive drug-taking. We will explore how these emotional dysregulations impact upon decision-making controlled by goal-directed and habitual action selections systems, and, in combination with a failure of prefrontal inhibitory control, mediate maladaptive decision-making observed in substance dependent individuals such that they continue drug use in spite of negative consequences. An understanding of the emotional impacts on cognition in substance dependent individuals may guide the development of more effective therapeutic interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.