ArticleFrontiers in neural circuits2012
Connectivity from OR37 expressing olfactory sensory neurons to distinct cell types in the hypothalamus.
Article in Frontiers in neural circuits, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice.Nature communications · 2024Article
- Sex-Specific Vasopressin Signaling Buffers Stress-Dependent Synaptic Changes in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Role of endothelin receptor type A on catecholamine regulation in the olfactory bulb of DOCA-salt hypertensive rats: Hemodynamic implications.Biochimica et biophysica acta. Molecular basis of disease · 2019Article
- Social modulation of fear: Facilitation vs buffering.Genes, brain, and behavior · 2019Review
- Structural and functional identification of two distinct inspiratory neuronal populations at the level of the phrenic nucleus in the rat cervical spinal cord.Brain structure & function · 2019Article
- The role of vasopressin in olfactory and visual processing.Cell and tissue research · 2019Review
- Ghrelin-containing neurons in the olfactory bulb send collateralized projections into medial amygdaloid and arcuate hypothalamic nuclei: neuroanatomical study.Experimental brain research · 2018Article
- Comparative studies of social buffering: A consideration of approaches, terminology, and pitfalls.Neuroscience and biobehavioral reviews · 2018Review
- Adult Born Periglomerular Cells of Odorant Receptor Specific Glomeruli.Frontiers in neuroanatomy · 2018Article
- Olfactory Performance as an Indicator for Protective Treatment Effects in an Animal Model of Neurodegeneration.Frontiers in integrative neuroscience · 2018Article
- Oxytocin and vasopressin neural networks: Implications for social behavioral diversity and translational neuroscience.Neuroscience and biobehavioral reviews · 2017Review
- The Evolving Neural and Genetic Architecture of Vertebrate Olfaction.Current biology : CB · 2016Review
- Vasopressin Proves Es-sense-tial: Vasopressin and the Modulation of Sensory Processing in Mammals.Frontiers in endocrinology · 2015Review
- Differential localization of NT-3 and TrpM5 in glomeruli of the olfactory bulb of mice.The Journal of comparative neurology · 2014Article
- DiI tracing of the hypothalamic projection systems during perinatal development.Frontiers in neuroanatomy · 2014Review
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Neural circuits mediating olfactory-driven behavior in fish.Frontiers in neural circuits · 2013Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory sensory neurons (OSNs) which express a member from the OR37 subfamily of odorant receptor (OR) genes are wired to the main olfactory bulb (MOB) in a unique monoglomerular fashion; from these glomeruli an untypical connectivity into higher brain centers exists. In the present study we have investigated by DiI and transsynaptic tracing approaches how the connection pattern from these glomeruli into distinct hypothalamic nuclei is organized. The application of DiI onto the ventral domain of the bulb which harbors the OR37 glomeruli resulted in the labeling of fibers within the paraventricular nucleus (PVN) and supraoptic nucleus (SO) of the hypothalamus; some of these fibers were covered with varicose-like structures. No DiI-labeled cell somata were detectable in these nuclei. The data indicate that projection neurons which originate in the OR37 region of the MOB form direct connections into these nuclei. The cells that were labeled by the transsynaptic tracer WGA in these nuclei were further characterized. Their distribution pattern in the paraventricular nucleus was reminiscent of cells which produce distinct neuropeptides. Double labeling experiments confirmed that they contained vasopressin, but not the related neuropeptide oxytocin. Morphological analysis revealed that they comprise of magno- and parvocellular cells. A comparative investigation of the WGA-positive cells in the SO demonstrated that these were vasopressin-positive, as well, whereas oxytocin-producing cells of this nucleus also contained no transsynaptic tracer. Together, the data demonstrates a connectivity from OR37 expressing sensory neurons to distinct hypothalamic neurons with the same neuropeptide content.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.