ArticleIndian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India2012
A comparative study of the effect of different topical agents on burn wound infections.
Article in Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
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- Reepithelialization of partial thickness porcine burns treated with silver sulfadiazine, triple antibiotic or petrolatum.Annals of burns and fire disasters · 2024Article
- Topical antimicrobials for burn infections - an update.Recent patents on anti-infective drug discovery · 2013Review
- Propolis induces chondroitin/dermatan sulphate and hyaluronic Acid accumulation in the skin of burned wound.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Application of electron paramagnetic resonance spectroscopy to comparative examination of different groups of free radicals in thermal injuries treated with propolis and silver sulphadiazine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Microwave Saturation of Complex EPR Spectra and Free Radicals of Burnt Skin Treated with Apitherapeutic Agent.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Wound-healing Activity ofPharmacognosy magazineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTopical agents are used to treat burn wound infections. AIMS AND
objectiveThe present work was aimed to find out the in vitro efficacy of different topical agents against burn wound pathogens. SETTINGS AND
designRandomly selected gram-positive (29) and gram-negative bacterial (119) isolates from burn wound cases admitted in burn unit of Choithram Hospital and Research Centre, Indore, were included in the in vitro activity testing for silver nitrate, silver sulphadiazine (SSD), chlorhexidine, cetrimide, nitrofuran, soframycin, betadine, benzalkonium chloride and honey by growth inhibition on agar medium. MATERIALS AND
methodsMultidrug-resistant isolates of gram-positive and gram-negative bacteria were checked for different topical agents. 1% topical agent was mixed with Mueller-Hinton agar. Two microlitres of bacterial suspension adjusted to 0.5 McFarland turbidity standard was spread over the topical agent containing plates. The plates without the topical agent were used as control plates. The plates were incubated for 48 h at 37°C.
resultsSSD (148/148), silver nitrate (148/148) and chlorhexidine (148/148) showed excellent activity against all the pathogens. Neosporin had poor activity against Pseudomonas aeruginosa, (4/44) Proteus spp. (2/4) and group D streptococci (1/4). Betadine did not show activity against the bacterial isolates in the presence of organic matter. Honey did not exert any antimicrobial activity under the study conditions.
conclusionSSD, silver nitrate and chlorhexidine have excellent activity against all the bacterial pathogens and could be used empirically, while identification of the infective agent is required for selecting the alternative topical agents such as nitrofuran, soframycin, and benzalkonium chloride.
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