ArticleIndian journal of psychological medicine2012
Effect of a single dose of dextromethorphan on psychomotor performance and working memory capacity.
Article in Indian journal of psychological medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Eustress and Malondialdehyde (MDA): Role of Panax Ginseng: Randomized Placebo Controlled Study.Iranian journal of psychiatry · 2017Article
- Central Beneficial Effects of Trimetazidine on Psychomotor Performance in Normal Healthy Volunteers.Advanced biomedical research · 2017Article
- Citicoline Improves Human Vigilance and Visual Working Memory: The Role of Neuronal Activation and Oxidative Stress.Basic and clinical neuroscienceArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies show that the prolonged use of dextromethorphan produces cognitive deterioration in humans.
aimThe aim of this study was to investigate the effect of a single dose of dextroemthrophan on psychomotor performance and working memory capacity. MATERIALS AND
methodsThis is a randomized, double-blind, controlled, and prospective study. Thirty-six (17 women, 19 men) medical students enrolled in the study; half of them (7 women, 11 men) were given placebo, while the other half (10 women, 8 men) received dextromethorphan. The choice reaction time, critical flicker fusion threshold, and N-back working memory task were measured before and after 2 h of taking the drugs.
resultsDextromethorphan showed a significant deterioration in the 3-back working memory task (P<0.05). No significant changes were seen as regards the choice reaction time components (total, recognition, motor) and critical flicker fusion threshold (P>0.05). On the other hand, placebo showed no significant changes as regards the choice reaction time, critical flicker fusion threshold, and N-back working memory task (P>0.05).
conclusionA single dose of dextromethorphan has no effect on attention and arousal but may significantly impair the working memory capacity.
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