ReviewBiotechnology journal2013
Raman spectroscopy in biomedicine - non-invasive in vitro analysis of cells and extracellular matrix components in tissues.
Review in Biotechnology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 136 citations in OpenAlex.
- Multimodal High-Throughput Screening Raman Spectroscopy for Label-Free Single-Cell Characterization of Recombinant Protein Production in Baculovirus Expression Vector Systems.Analytical chemistry · 2026Article
- Review
- Raman Spectroscopy for Testing Wood Pellets.Methods and protocols · 2025Article
- The characterization of halophilic polyhydroxyalkanoate-producing bacteria from brine in Solivar near Prešov (Slovakia).World journal of microbiology & biotechnology · 2025Article
- Distinct Spectral Profiles of Pleural Effusions from Malignant Tumors Using Raman Spectroscopy.International journal of molecular sciences · 2025Article
- Engineering Nanomaterials for Raman Bioimaging and Theranostics: Advances, Challenges, and Future Directions.ACS omega · 2025Review
- Spectroscopic Insights into the Localization and Photodynamic Efficacy of Aluminum Tetrasulfonated Phthalocyanine for Colorectal Cancer Therapy.The journal of physical chemistry. B · 2025Article
- Determination of Raman spectrum under different culture conditions: preliminary research on bacterial fish pathogens.Animal biotechnology · 2024Article
- SERS in 3D cell models: a powerful tool in cancer research.Chemical Society reviews · 2024Review
- The Regenerative Microenvironment of the Tissue Engineering for Urethral Strictures.Stem cell reviews and reports · 2024Review
- Label-free biomedical optical imaging.Nature photonics · 2023Article
- Molecular Fingerprint Detection Using Raman and Infrared Spectroscopy Technologies for Cancer Detection: A Progress Review.Biosensors · 2023Review
- In vivo non-invasive monitoring of tissue development in 3D printed subcutaneous bone scaffolds using fibre-optic Raman spectroscopy.Biomaterials and biosystems · 2022Article
- Non-Invasive Three-Dimensional Cell Analysis in Bioinks by Raman Imaging.ACS applied materials & interfaces · 2022Article
- Microphysiological stem cell models of the human heart.Materials today. Bio · 2022Review
- Compositional assessment of bone by Raman spectroscopy.The Analyst · 2021Review
- Diagnosis of Dental Fluorosis Using Micro-Raman Spectroscopy Applying a Principal Component-Linear Discriminant Analysis.International journal of environmental research and public health · 2021Article
- Adsorption/Desorption Behaviors and SERS Chemical Enhancement of 6-Mercaptopurine on a Nanostructured Gold Surface: The AuMolecules (Basel, Switzerland) · 2021Article
- Laparoscopic Peritoneal Wash Cytology-Derived Primary Human Mesothelial Cells for In Vitro Cell Culture and Simulation of Human Peritoneum.Biomedicines · 2021Article
- Melanins as Sustainable Resources for Advanced Biotechnological Applications.Global challenges (Hoboken, NJ) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Raman spectroscopy is an established laser-based technology for the quality assurance of pharmaceutical products. Over the past few years, Raman spectroscopy has become a powerful diagnostic tool in the life sciences. Raman spectra allow assessment of the overall molecular constitution of biological samples, based on specific signals from proteins, nucleic acids, lipids, carbohydrates, and inorganic crystals. Measurements are non-invasive and do not require sample processing, making Raman spectroscopy a reliable and robust method with numerous applications in biomedicine. Moreover, Raman spectroscopy allows the highly sensitive discrimination of bacteria. Rama spectra retain information on continuous metabolic processes and kinetics such as lipid storage and recombinant protein production. Raman spectra are specific for each cell type and provide additional information on cell viability, differentiation status, and tumorigenicity. In tissues, Raman spectroscopy can detect major extracellular matrix components and their secondary structures. Furthermore, the non-invasive characterization of healthy and pathological tissues as well as quality control and process monitoring of in vitro-engineered matrix is possible. This review provides comprehensive insight to the current progress in expanding the applicability of Raman spectroscopy for the characterization of living cells and tissues, and serves as a good reference point for those starting in the field.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.