ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2013
Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Development and regeneration of the vagus nerve.Seminars in cell & developmental biology · 2024Review
- A chemorepellent inhibits local Ras activation to inhibit pseudopod formation to bias cell movement away from the chemorepellent.Molecular biology of the cell · 2022Article
- Innervation in organogenesis.Current topics in developmental biology · 2022Article
- Microbial influences on gut development and gut-brain communication.Development (Cambridge, England) · 2021Review
- Development of the Autonomic Nervous System: Clinical Implications.Seminars in neurology · 2020Review
- Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- You Are What You (First) Eat.Frontiers in human neuroscience · 2018Review
- Kif1bp loss in mice leads to defects in the peripheral and central nervous system and perinatal death.Scientific reports · 2017Article
- Are Molecules Involved in Neuritogenesis and Axon Guidance Related to Autism Pathogenesis?Neuromolecular medicine · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe vagus nerve descends from the brain to the gut during fetal life to reach specific targets in the bowel wall. Vagal sensory axons have been shown to respond to the axon guidance molecule netrin and to its receptor, deleted in colorectal cancer (DCC). As there are regions of the gut wall into which vagal axons do and do not extend, it is likely that a combination of attractive and repellent cues are involved in how vagal axons reach specific targets. We tested the hypothesis that Slit/Robo chemorepulsion can contribute to the restriction of vagal sensory axons to specific targets in the gut wall.
resultsTranscripts encoding Robo1 and Robo2 were expressed in the nodose ganglia throughout development and mRNA encoding the Robo ligands Slit1, Slit2, and Slit3 were all found in the fetal and adult bowel. Slit2 protein was located in the outer gut mesenchyme in regions that partially overlap with the secretion of netrin-1. Neurites extending from explanted nodose ganglia were repelled by Slit2.
conclusionsThese observations suggest that vagal sensory axons are responsive to Slit proteins and are thus repelled by Slits secreted in the gut wall and prevented from reaching inappropriate targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.