ArticleNeuro-oncology2013
MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2.
Article in Neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- MicroRNA expression profiling of Xp11 renal cell carcinoma.Human pathology · 2017Pooled it
- Prognostic role of microRNA-21 expression in gliomas: a meta-analysis.Journal of neuro-oncology · 2016Pooled it
- MiR-1248: a new prognostic biomarker able to identify supratentorial hemispheric pediatric low-grade gliomas patients associated with progression.Biomarker research · 2022Article
- Noncoding RNAs in pediatric brain tumors: Molecular functions and pathological implications.Molecular therapy. Nucleic acids · 2021Review
- Reimagining pilocytic astrocytomas in the context of pediatric low-grade gliomas.Neuro-oncology · 2021Review
- Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.Journal of neuro-oncology · 2020Article
- Review
- Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors.BMC cancer · 2019Article
- Upregulation of MicroRNA-21 promotes tumorigenesis of prostate cancer cells by targeting KLF5.Cancer biology & therapy · 2019Article
- MicroRNA profile of pediatric pilocytic astrocytomas identifies two tumor-specific signatures when compared to non-neoplastic white matter.Journal of neuro-oncology · 2019Article
- Specific miRNA expression profile in the blood serum of cardiac myxoma patients.Oncology letters · 2018Article
- MicroRNA (miR) 125b regulates cell growth and invasion in pediatric low grade glioma.Scientific reports · 2018Article
- INSM1 Expression Is Frequent in Primary Central Nervous System Neoplasms but Not in the Adult Brain Parenchyma.Journal of neuropathology and experimental neurology · 2018Article
- Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.Cell reports · 2018Article
- The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors.International journal of molecular sciences · 2018Review
- Suppression of glioblastoma growth and angiogenesis through molecular targeting of methionine aminopeptidase-2.Journal of neuro-oncology · 2018Article
- Explorative visual analytics on interval-based genomic data and their metadata.BMC bioinformatics · 2017Article
- Expression of microRNAs in tumors of the central nervous system in pediatric patients in México.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2017Article
- miR-217-casein kinase-2 cross talk regulates ERK activation in ganglioglioma.Journal of molecular medicine (Berlin, Germany) · 2017Article
- A composite network of conserved and tissue specific gene interactions reveals possible genetic interactions in glioma.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Pilocytic astrocytoma (PA) is a World Health Organization grade I glioma that occurs most commonly in children and young adults. Specific genetic alterations have been described in PA, but the pathogenesis remains poorly understood. We studied microRNA (miRNA) alterations in a large cohort of patients with PA. A total of 43 PA, including 35 sporadic grade I PA, 4 neurofibromatosis-1 (NF1)-associated PA, and 4 PA with pilomyxoid features, as well as 5 nonneoplastic brain controls were examined. BRAF fusion status was assessed in most cases. RNA was examined using the Agilent Human miRNA Microarray V3 platform. Expression of miRNA subsets was validated using quantitative real-time PCR (qRT-PCR) with Taqman probes. Validation of predicted protein targets was performed on tissue microarrays with the use of immunohistochemistry. We identified a subset of miRNAs that were differentially expressed in pediatric PAs versus normal brain tissue: 13 miRNAs were underexpressed, and 20 miRNAs were overexpressed in tumors. Differences were validated by qRT-PCR in a subset, with mean fold change in tumor versus brain of -17 (miR-124), -15 (miR-129), and 19.8 (miR-21). Searching for predicted protein targets in Targetscan, we identified a number of known and putative oncogenes that were predicted targets of miRNA sets relatively underexpressed in PA. Predicted targets with increased expression at the mRNA and/or protein level in PA included PBX3, METAP2, and NFIB. A unique miRNA profile exists in PA, compared with brain tissue. These miRNAs and their targets may play a role in the pathogenesis of PA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.