ArticleElectrophoresis2012
Fabrication and characterization of nanopores with insulated transverse nanoelectrodes for DNA sensing in salt solution.
Article in Electrophoresis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Detecting DNA Translocation through a Nanopore using a van der Waals Heterojunction Diode.Research square · 2025Article
- Electromigrated Gold Nanogap Tunnel Junction Arrays: Fabrication and Electrical Behavior in Liquid and Gaseous Media.ACS applied materials & interfaces · 2024Article
- Understanding Electrical Conduction and Nanopore Formation During Controlled Breakdown.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations.Nature communications · 2021Article
- Article
- Lifetime and Stability of Silicon Nitride Nanopores and Nanopore Arrays for Ionic Measurements.ACS nano · 2020Article
- Optically-Monitored Nanopore Fabrication Using a Focused Laser Beam.Scientific reports · 2018Article
- Solid-state nanopore localization by controlled breakdown of selectively thinned membranes.Nanotechnology · 2017Article
- Conductivity-based detection techniques in nanofluidic devices.The Analyst · 2015Review
- Fundamental studies of nanofluidics: nanopores, nanochannels, and nanopipets.Analytical chemistry · 2015Review
- Fixed-gap tunnel junction for reading DNA nucleotides.ACS nano · 2014Article
- Article
- The evolution of nanopore sequencing.Frontiers in genetics · 2014Review
- Article
- Electrically controlled nanoparticle synthesis inside nanopores.Nano letters · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We report on the fabrication, simulation, and characterization of insulated nanoelectrodes aligned with nanopores in low-capacitance silicon nitride membrane chips. We are exploring these devices for the transverse sensing of DNA molecules as they are electrophoretically driven through the nanopore in a linear fashion. While we are currently working with relatively large nanopores (6-12 nm in diameter) to demonstrate the transverse detection of DNA, our ultimate goal is to reduce the size sufficiently to resolve individual nucleotide bases, thus sequencing DNA as it passes through the pore. We present simulations and experiments that study the impact of insulating these electrodes, which is important to localize the sensing region. We test whether the presence of nanoelectrodes or insulation affects the stability of the ionic current flowing through the nanopore, or the characteristics of DNA translocation. Finally, we summarize the common device failures and challenges encountered during fabrication and experiments, explore the causes of these failures, and make suggestions on how to overcome them in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.