ArticleMagnetic resonance in medicine2013
Fat confounds the observed apparent diffusion coefficient in patients with hepatic steatosis.
Article in Magnetic resonance in medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Water/Fat Separated Echo Planar Time-Resolved Imaging (WFS-EPTI) for Distortion-Free Multi-Contrast MRI.Magnetic resonance in medicine · 2026Article
- Development and validation of fat-corrected virtual MR elastography to assess fibrosis stage in metabolic dysfunction-associated steatotic liver disease.Insights into imaging · 2026Article
- Enhanced diagnostic performance of WE-SHARP-DWI compared with SPAIR-DWI for focal liver lesion evaluation at 3T.Abdominal radiology (New York) · 2026Article
- Fatty liver regeneration after partial hepatectomy: an experimental study based on intravoxel incoherent motion and T2Magma (New York, N.Y.) · 2026Article
- Fat-Corrected Non-Gaussian Diffusion MRI for Liver Fibrosis Assessment in Metabolic Dysfunction-Associated Steatotic Liver Disease.Journal of magnetic resonance imaging : JMRI · 2026Article
- Overestimation of the Apparent Diffusion Coefficient in Diffusion-Weighted Imaging Due to Residual Fat Signal and Out-of-Phase Conditions.Tomography (Ann Arbor, Mich.) · 2026Article
- Fat-signal suppression in breast diffusion-weighted imaging: the Good, the Bad, and the Ugly.European radiology · 2025Article
- Understanding ADC variation by fat content effect using a dual-function MRI phantom.European radiology experimental · 2024Article
- Monte Carlo modeling of hepatic steatosis based on stereology and spatial distribution of fat droplets.Computer methods and programs in biomedicine · 2023Article
- Technical Advancements in Abdominal Diffusion-weighted Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Review
- Quantitative diffusion MRI of the abdomen and pelvis.Medical physics · 2022Article
- Gender-specific liver aging and magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2021Article
- Intravoxel incoherent motion diffusion-weighted MRI for the characterization of inflammation in chronic liver disease.European radiology · 2021Article
- Diffusion-weighted MRI of the liver: challenges and some solutions for the quantification of apparent diffusion coefficient and intravoxel incoherent motion.American journal of nuclear medicine and molecular imaging · 2021Review
- Diffusion tensor imaging quantifying the severity of chronic hepatitis in rats.BMC medical imaging · 2020Article
- Topics on quantitative liver magnetic resonance imaging.Quantitative imaging in medicine and surgery · 2019Review
- Quantitative MRI and spectroscopy of bone marrow.Journal of magnetic resonance imaging : JMRI · 2018Review
- An acetone-based phantom for quantitative diffusion MRI.Journal of magnetic resonance imaging : JMRI · 2017Article
- Renal Adiposity Confounds Quantitative Assessment of Markers of Renal Diffusion With MRI: A Proposed Correction Method.Investigative radiology · 2017Article
- Liver histology and diffusion-weighted MRI in children with nonalcoholic fatty liver disease: A MAGNET study.Journal of magnetic resonance imaging : JMRI · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
purposeTriglyceride signal contained in peaks near the water peak remains unsuppressed by conventional fat suppression techniques used in diffusion-weighted imaging. In this work, we investigated the dependence of the apparent diffusion coefficient (ADC) on liver fat content and whether it is confounded by fat signal.
methods43 patients underwent liver diffusion-weighted imaging (b = 0, 500 s/mm(2)) and single-voxel MR-spectroscopy. Proton density fat-fraction (PDFF; range 0.23-34.5%) was measured from MR-spectroscopy. A theoretical model was developed to account for the effects of fat on observed ADC, and used to correct the ADC. Linear correlation analysis was performed to assess the relationship between PDFF and ADC before and after correction.
resultsLinear correlation analysis showed an inverse dependence between observed ADC and PDFF before correction (r(2) = 0.132; P = 0.017), and no dependence after correction (r(2) = 0.033; P = 0.24).
conclusionThe observed decrease in ADC in patients with fatty liver is, at least in part, artifactual due to residual fat signal near the water peak.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.