Trial reportEuropean archives of psychiatry and clinical neuroscience2013
The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study.
Trial report in European archives of psychiatry and clinical neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Randomised controlled cognition trials in remitted patients with mood disorders published between 2015 and 2021: A systematic review by the International Society for Bipolar Disorders Targeting Cognition Task Force.Bipolar disorders · 2022Pooled it
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- Neural correlates of exercise training in individuals with schizophrenia and in healthy individuals: A systematic review.NeuroImage. Clinical · 2018Pooled it
- The pro-cognitive mechanisms of physical exercise in people with schizophrenia.British journal of pharmacology · 2017Pooled it
- Exercise Improves Clinical Symptoms, Quality of Life, Global Functioning, and Depression in Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2016Pooled it
- Brain Structural Effects of Antipsychotic Treatment in Schizophrenia: A Systematic Review.Current neuropharmacology · 2015Pooled it
- A combined exercise and cognitive training intervention induces fronto-cingulate cortical plasticity in first-episode psychosis patients.Schizophrenia research · 2023Trial
- Effects of body-oriented yoga: a RCT study for patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2021Trial
- Effects of exercise-based interventions in severe mental illness: a feasibility study.European archives of psychiatry and clinical neuroscience · 2019Trial
- Repetitive Transcranial Magnetic Stimulation for the Treatment of Executive Function Deficits in Autism Spectrum Disorder: Clinical Trial Approach.Journal of child and adolescent psychopharmacology · 2017Trial
- Hippocampal structure, metabolism, and inflammatory response after a 6-week intense aerobic exercise in healthy young adults: a controlled trial.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Trial
- Physical Exercise Keeps the Brain Connected: Biking Increases White Matter Integrity in Patients With Schizophrenia and Healthy Controls.Schizophrenia bulletin · 2015Trial
- Effects of aerobic exercise on cognitive performance and individual psychopathology in depressive and schizophrenia patients.European archives of psychiatry and clinical neuroscience · 2014Trial
- Effect of Dance Intervention on Cognitive Function and Related Cerebellar Dynamic Functional Connectivity in Patients With Schizophrenia.Alpha psychiatry · 2026Article
- Effects of aerobic training on brain architecture, hippocampal volume, cardiorespiratory parameters, and health-related quality of life among patients with schizophrenia: A systematic review.Indian journal of psychiatry · 2024Review
- The Effect of Physical Exercise on People with Psychosis: A Qualitative Critical Review of Neuroimaging Findings.Brain sciences · 2023Review
- Physical exercise keeps the brain connected by increasing white matter integrity in healthy controls.Medicine · 2021Article
- [The CIMH track concept in the treatment of psychotic disorders].Der Nervenarzt · 2020Article
- On the Run for Hippocampal Plasticity.Cold Spring Harbor perspectives in medicine · 2018Review
- Exercise Treatments for Psychosis: A Review.Current treatment options in psychiatry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Via influencing brain plasticity, aerobic exercise could contribute to the treatment of schizophrenia patients. As previously shown, physical exercise increases hippocampus volume and improves short-term memory. We now investigated gray matter density and brain surface expansion in this sample using MRI-based cortical pattern matching methods. Comparing schizophrenia patients to healthy controls before and after 3 months of aerobic exercise training (cycling) plus patients playing table football yielded gray matter density increases in the right frontal and occipital cortex merely in healthy controls. However, respective exercise effects might be attenuated in chronic schizophrenia, which should be verified in a larger sample.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.