ArticleCellular and molecular neurobiology2013
Effects of intracavernous injection of adipose-derived stem cells on cavernous nerve regeneration in a rat model.
Article in Cellular and molecular neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Adipose tissue-derived stem cell therapy for erectile dysfunction in rats: a systematic review and meta-analysis.International urology and nephrology · 2017Pooled it
- Stem cell therapy for erectile dysfunction of cavernous nerve injury rats: a systematic review and meta-analysis.PloS one · 2015Pooled it
- Stem cell therapy for erectile dysfunction: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- Adipose-derived stem cells modified byNeural regeneration research · 2020Article
- MicroRNA-145 engineered bone marrow-derived mesenchymal stem cells alleviated erectile dysfunction in aged rats.Stem cell research & therapy · 2019Article
- Adipose Tissue-Derived Stem Cell Therapy for Cavernous Nerve Injury-Induced Erectile Dysfunction in the Rat Model: A Systematic Review and Meta-Analysis Using Methodological Quality Assessment.International journal of stem cells · 2019Review
- Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats.Neural regeneration research · 2019Article
- The mechanisms and potential of stem cell therapy for penile fibrosis.Nature reviews. Urology · 2019Review
- Whole genome mRNA expression profiling revealed multiple deregulated pathways in stromal vascular fraction from erectile dysfunction patients.Bioscience reports · 2018Article
- The role of undifferentiated adipose-derived stem cells in peripheral nerve repair.Neural regeneration research · 2018Article
- Effects of adipose-derived stem cells plus insulin on erectile function in streptozotocin-induced diabetic rats.International urology and nephrology · 2016Article
- The potential roles for adipose tissue in peripheral nerve regeneration.Microsurgery · 2016Review
- The potential of cell-based therapy for diabetes and diabetes-related vascular complications.Current diabetes reports · 2014Review
- Stem-cell therapy for erectile dysfunction.Arab journal of urology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate effects of intracavernous injection of adipose-derived stem cells (ADSCs) on cavernous nerve (CN) regeneration and functional status in a nerve-crush rat model. Thirty Sprague-Dawley male rats were randomly divided into three equal groups: one group underwent sham operation, while two groups underwent bilateral CN crush. Crush-injury group was treated at the time of injury with intracavernous injection of ADSCs, or injured control group with no further intervention. Erectile function was assessed by CN electrostimulation after 3 months. Penile tissue and crushed nerves were collected for histology. Three months after surgery, in the group that underwent bilateral nerve crushing with no further intervention, the functional evaluation showed a lower mean maximal intracavernous pressure (ICP) and maximal ICP per mean arterial pressure (MAP) with CN stimulation than those in the sham group. In the group with an immediate intracavernous injection of ADSCs, the mean maximal ICP and maximal ICP/MAP were significantly higher than those in the injured control group. Histologically, the group with the intracavernous injection of ADSCs had more myelinated axons of CNs and more NADPH-diaphorase-positive nerve fibers than the injured control group but fewer than the sham group. Intracavernous injection of ADSCs treatment had beneficial effects on the smooth muscle/collagen ratio in the corpus cavernosum. These results show that the intracavernous injection of ADSCs to the site of CN-crush injury facilitates nerve regeneration and recovery of erectile function. Our research indicates that penile injection of ADSCs can improve recovery of erectile function in a rat model of neurogenic ED.
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